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Ultrasound-assisted extraction of four groups of Osmanthus fragrans fruit: Optimization, UPLC-Orbitrap-MS/MS characterization and anti-inflammatory activity evaluation
- Source :
- Arabian Journal of Chemistry, Vol 14, Iss 4, Pp 103086-(2021)
- Publication Year :
- 2021
- Publisher :
- Elsevier, 2021.
-
Abstract
- In this study, simultaneous optimization of ultrasound-assistant extraction (UAE) of four representative groups of Osmanthus fragrans (OF) fruit was firstly performed using the response surface methodology (RSM). Subsequently, qualitative and quantitative analysis of irioid glycosides from the optimized OF fruit extract was performed using UPLC-ESI-Orbitrap-MS/MS. A total of 13 irioid glycosides were tentatively identified, of which six compounds were identified for the first time. Finally, the anti-inflammatory activity of the optimized OF var. aurantiacus Makino (OFA) fruit extract was evaluated based on a CuSO4-induced zebra fish model. The biological results demonstrated that OFA fruit extract at a concentration of 5 μg/mL could significantly reduce the number of macrophages, but no significant activities were observed at high concentrations (10 and 50 μg/mL). These results suggest that OF fruit has the promise as a functional additive in food for health promotion.
- Subjects :
- medicine.drug_class
General Chemical Engineering
02 engineering and technology
010402 general chemistry
01 natural sciences
High-performance liquid chromatography
Anti-inflammatory
lcsh:Chemistry
Anti-inflammatory activity
Osmanthus fragrans fruit
medicine
Response surface methodology
chemistry.chemical_classification
Chromatography
biology
Zebra fish
Orbitrap ms
Extraction (chemistry)
Osmanthus fragrans
Glycoside
Iridoid glycosides
General Chemistry
021001 nanoscience & nanotechnology
biology.organism_classification
0104 chemical sciences
chemistry
lcsh:QD1-999
Ultrasound-assisted extraction
0210 nano-technology
Quantitative analysis (chemistry)
Subjects
Details
- Language :
- English
- ISSN :
- 18785352
- Volume :
- 14
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Arabian Journal of Chemistry
- Accession number :
- edsair.doi.dedup.....dd38a56ca55dcc2344dc68d760dfa47b