Back to Search Start Over

Effect of Cognitive Reserve on Physiological Measures of Cognitive Workload in Older Adults with Cognitive Impairments

Authors :
Hannes Devos
Kathleen Gustafson
Ke Liao
Pedram Ahmadnezhad
Emily Kuhlmann
Bradley Estes
Laura E. Martin
Jonathan D. Mahnken
William M. Brooks
Jeffrey M. Burns
Source :
J Alzheimers Dis
Publication Year :
2023
Publisher :
IOS Press, 2023.

Abstract

BackgroundCognitive reserve may protect against cognitive decline. However, its effect on physiological measures of cognitive workload in adults with cognitive impairments is unclear.ObjectiveThe aim was to determine the association between cognitive reserve and physiological measures of cognitive workload in older adults with and without cognitive impairments.Methods29 older adults with cognitive impairment (age: 75±6, 11 (38%) women, MOCA scores 20±7) and 19 with normal cognition (age: 74±6; 11 (58%) women; MOCA 28±2) completed a working memory test of increasing task demand (0-, 1-, 2-back). Cognitive workload was indexed using amplitude and latency of the P3 event-related potential (ERP) at electrode sites Fz, Cz, and Pz, and changes in pupillary size, converted to an index of cognitive activity (ICA). The Cognitive Reserve Index questionnaire (CRIq) evaluated Education, Work Activity, and Leisure Time as a proxy of cognitive reserve.ResultsHigher CRIq total scores were associated with larger P3 ERP amplitude (p=0.048), independent of cognitive status (p=0.80), task demand (p=0.003), and electrode site (pConclusionCognitive reserve affects cognitive workload and neural efficiency, regardless of cognitive status. Future longitudinal studies should investigate the causal relationship between cognitive reserve and physiological processes of neural efficiency across cognitive aging.

Details

ISSN :
18758908 and 13872877
Volume :
92
Database :
OpenAIRE
Journal :
Journal of Alzheimer's Disease
Accession number :
edsair.doi.dedup.....dd68f75d4e8daf870de312eb2d7117d4
Full Text :
https://doi.org/10.3233/jad-220890