Orally Bioavailable Quinoxaline Inhibitors of 15-Prostaglandin Dehydrogenase (15-PGDH) Promote Tissue Repair and Regeneration

Authors :: Bin Hu
Kosuke Toda
Xiaoyu Wang
Monika I. Antczak
Julianne Smith
Sophie Geboers
Gen Nishikawa
Hongyun Li
Dawn Dawson
Stephen Fink
Amar B. Desai
Noelle S. Williams
Sanford D. Markowitz
Joseph M. Ready
Source :: Journal of Medicinal Chemistry. 65:15327-15343
Publication Year :: 2022
Publisher :: American Chemical Society (ACS), 2022.
Abstract: 15-Prostaglandin dehydrogenase (15-PGDH) regulates the concentration of prostaglandin E2

Subjects :: Mice
Quinoxalines
Drug Discovery
Hydroxyprostaglandin Dehydrogenases
Animals
Molecular Medicine
Colitis, Ulcerative
Dinoprostone

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