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Prognostic Values of LAPTM4B-35 in Human Cancer: A Meta-analysis
- Source :
- Journal of Cancer
- Publication Year :
- 2018
- Publisher :
- Ivyspring International Publisher, 2018.
-
Abstract
- Background: Lysosome-associated protein transmembrane-4β-35(LAPTM4B-35) has been observed overexpressed in multiple malignant tumors. However, the prognostic value of LAPTM4B-35 remains controversial. Therefore, we conducted a meta-analysis to evaluate the prognostic value of LAPTM4B-35 in human cancers. Methods: The relevant publications were obtained by systematically searching the PubMed, Web of Science, Embase, Wanfang, and China National Knowledge Infrastructure (CNKI) databases. Pooled hazard ratios (HRs) with 95% confidence intervals (CIs) were calculated for the prognosis value of LAPTM4B-35 for cancer patient. Results: Our result suggest that LAPTM4B-35 overexpression is significantly associated with poor overall survival (OS) (HR = 2.49, 95% CI = 1.87-3.32, p < 0.001), disease-free survival (DFS) (HR = 2.43, 95% CI = 1.35-4.35, p = 0.003), and progression-free survival (PFS) (HR = 4.12, 95% CI = 2.30-7.37, p < 0.001). Moreover, subgroup analysis revealed significant association with poor OS in lung (HR = 2.05, 95% CI = 1.37-3.06, p < 0.001), gastric carcinoma (HR = 1.88, 95% CI = 1.01-3.50, p < 0.047) and ovarian cancer (HR = 4.94, 95% CI = 1.44-16.94, p = 0.011). Conclusion: LAPTM4B-35 may be a novel predictive biomarker and a potential target for treatment.
- Subjects :
- 0301 basic medicine
Oncology
medicine.medical_specialty
Subgroup analysis
03 medical and health sciences
0302 clinical medicine
LAPTM4B
Internal medicine
medicine
cancer
business.industry
LAPTM4B-35
Hazard ratio
Cancer
medicine.disease
Confidence interval
meta-analysis
030104 developmental biology
030220 oncology & carcinogenesis
Meta-analysis
prognosis
Ovarian cancer
business
Human cancer
Research Paper
Subjects
Details
- Language :
- English
- ISSN :
- 18379664
- Volume :
- 9
- Issue :
- 23
- Database :
- OpenAIRE
- Journal :
- Journal of Cancer
- Accession number :
- edsair.doi.dedup.....ddaa7167f7f75d97c463e6bab0ae6e95