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4,4′-diaponeurosporene, a C30 carotenoid, effectively activates dendritic cellsviaCD36 and NF-κB signaling in a ROS independent manner
- Source :
- Oncotarget
- Publication Year :
- 2016
- Publisher :
- Impact Journals, LLC, 2016.
-
Abstract
- Carotenoids could be divided into C30 carotenoids and C40 carotenoids. The immune functions of C40 carotenoids had been extensively researched, while those of C30 carotenoids still remain unclear. In this study, the immune functions of a biosynthetic C30 carotenoid, 4,4′-diaponeurosporene (Dia), were identified on dendritic cells (DCs). DCs treated with 1 μM Dia for 24 h showed morphologic and phenotypic characteristics of mature state and had an increased production of IL-6, IL-10, IL-12p70 and TNFα, while β-carotene had a suppressive effect on DCs maturation. Moreover, Dia promoted antigen uptake of DCs in vitro and increased the quantity of antigen loaded DCs in mesenteric lymph nodes (MLN). Dia-treated DCs also had an enhanced ability to stimulate T cell proliferation and Th1 polarization. Further researches showed that Dia activated DCs via CD36 as well as ERK, JNK, and NF-κB signals in a reactive oxygen species (ROS) independent manner.
- Subjects :
- CD36 Antigens
0301 basic medicine
C30 carotenoids
Cellular differentiation
T cell
chemical and pharmacologic phenomena
Biology
Lymphocyte Activation
Mice
03 medical and health sciences
Immune system
Antigen
medicine
Animals
Mesenteric lymph nodes
Immune response
Cells, Cultured
chemistry.chemical_classification
Reactive oxygen species
030102 biochemistry & molecular biology
NF-kappa B
Research Paper: Immunology
Immunity
food and beverages
Cell Differentiation
hemic and immune systems
Dendritic Cells
Carotenoids
Triterpenes
Cell biology
Mice, Inbred C57BL
030104 developmental biology
medicine.anatomical_structure
Oncology
chemistry
4′-diaponeurosporene
Immunology
Immunology and Microbiology Section
Tumor necrosis factor alpha
Signal transduction
Reactive Oxygen Species
CD36
Signal Transduction
Subjects
Details
- ISSN :
- 19492553
- Volume :
- 7
- Database :
- OpenAIRE
- Journal :
- Oncotarget
- Accession number :
- edsair.doi.dedup.....ddc27fa1488157c4b3b5b1e6511fbcf1