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Endothelial Nitric Oxide Synthase T-786C Mutation, Prothrombin Gene Mutation (G-20210-A) and Protein S Deficiency Could Lead to Myocardial Infarction in a Very Young Male Adult
- Source :
- Open Access Macedonian Journal of Medical Sciences, Open Access Macedonian Journal of Medical Sciences; Vol. 4 No. 1 (2016): Mar 15 (OAMJMS); 142-145, Open Access Macedonian Journal of Medical Sciences, Vol 4, Iss 1, Pp 142-145 (2016), Open Access Macedonian Journal of Medical Sciences; Vol 4, No 1 (2016): Mar 15 (OAMJMS); 142-145
- Publication Year :
- 2016
- Publisher :
- Scientific Foundation SPIROSKI, 2016.
-
Abstract
- INTRODUCTION: Myocardial infarction is a rare medical event in young people. The main reasons include congenital coronary abnormalities, coronary artery spasm, and coronary thrombosis due to hypercoagulable states (hereditary and acquired).AIM: We present a case of a young male adult with myocardial infarction caused by a combination of gene mutations and anticoagulation protein deficiency.CASE PRESENTATION: A 19 years old young man was admitted to our hospital complaining of chest pain during the last two weeks. The patient did not have any known cardiovascular risk factors, except a positive family anamnesis. Subacute inferior nonST segment myocardial infarction was diagnosed according to the patient’s history, electrocardiographic and laboratory findings. Coronary angiography revealed suboclusive thrombus in the proximal, medial and distal part of the right coronary artery (TIMI 2). Percutaneous coronary intervention was performed. Anticoagulant and antiagregant therapy (heparin, acetilsalicilic acid and clopidogrel) according to protocol was started. The hospital stay was uneventful. Homozygous endothelial nitric oxid synthase (eNOS) T-786-C mutation, heterozygote prothrombin gene mutation (G-20210-A), and protein S deficiency were verified from the thrombophilia testing. Other trombophilic tests were normal. Three months after discharge from hospital another coronary angiography was performed. It revealed normal coronary arteries. Four years after the attack, the patient is free of symptoms and another cardiovascular event.CONCLUSION: Combination of genetic mutations and anticoagulation protein deficiency could be a reasonable cause for myocardial infarction in a very young male adult without any other cardiovascular risk factors.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
medicine.medical_treatment
prothrombin gene mutation (G-20210-A)
lcsh:Medicine
Case Report
030204 cardiovascular system & hematology
Gene mutation
Thrombophilia
Chest pain
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine.artery
medicine
Myocardial infarction
protein S deficiency
business.industry
lcsh:R
Percutaneous coronary intervention
General Medicine
medicine.disease
Clopidogrel
young male
(eNOS) T-786C mutation
myocardial infarction
030104 developmental biology
Right coronary artery
Cardiology
Medicine
Surgery
medicine.symptom
business
TIMI
medicine.drug
Subjects
Details
- ISSN :
- 18579655
- Volume :
- 4
- Database :
- OpenAIRE
- Journal :
- Open Access Macedonian Journal of Medical Sciences
- Accession number :
- edsair.doi.dedup.....ddd7c184eec0b1ba2b2a0a874a8de316