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Slowly progressive interstitial lung disease preceding typical dermatomyositis symptoms in anti-melanoma differentiation-associated gene 5 antibody-positive clinically amyopathic dermatomyositis
- Source :
- Respiratory Medicine Case Reports, Vol 34, Iss, Pp 101491-(2021), Respiratory Medicine Case Reports
- Publication Year :
- 2021
- Publisher :
- Elsevier, 2021.
-
Abstract
- A 73-year-old woman who visited our hospital complaining of dry cough for three months was refractory to antimicrobial therapy. Chest computed tomography revealed subpleural consolidation. Specimens obtained from surgical lung biopsy revealed subpleural perilobular airspace organization and fibrosis. After the biopsy, mechanic's hand and Gottron's papules appeared, and anti-melanoma differentiation-associated gene 5 (MDA5) antibody was found to be positive. Subsequently, anti-MDA5 antibody measured in cryopreserved serum from her first admission proved to be positive. It is difficult to suspect the presence of anti-MDA-5 antibody in patients with interstitial lung disease without typical dermatomyositis symptoms or slow disease progression.
- Subjects :
- Pulmonary and Respiratory Medicine
Pathology
medicine.medical_specialty
Case Report
Interstitial lung disease
Lung biopsy
IVCY, intravenous cyclophosphamide
Anti-melanoma differentiation-associated gene 5
Surgical lung biopsy
Diseases of the respiratory system
Clinically amyopathic dermatomyositis
Refractory
Fibrosis
PSL, prednisolone
Biopsy
CADM, clinically amyopathic dermatomyositis
RP-ILD, rapidly progressive interstitial lung disease
PaO2, partial pressure of oxygen
Medicine
SLB, surgical lung biopsy
DM, dermatomyositis
TBLB, transbronchial lung biopsy
medicine.diagnostic_test
biology
RC705-779
business.industry
MDA5, anti-melanoma differentiation-associated gene 5
MDA5
CMV, cytomegalovirus
Dermatomyositis
medicine.disease
CT, computed tomography
KL-6, Krebs von den Lungen-6
Slowly progressive
biology.protein
ANCA, cytoplasmic autoantibody
ILD, interstitial lung disease
HRCT, high-resolution computed tomography
BAL, bronchoalveolar lavage
Antibody
business
Subjects
Details
- Language :
- English
- ISSN :
- 22130071
- Volume :
- 34
- Database :
- OpenAIRE
- Journal :
- Respiratory Medicine Case Reports
- Accession number :
- edsair.doi.dedup.....dde5cbe048de7b0b8557c7538c3d40f9