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Reward processing dysfunction in ventral striatum and orbitofrontal cortex in Parkinson's disease
- Source :
- Parkinsonism & related disorders, 48, 82. Elsevier BV
- Publication Year :
- 2018
-
Abstract
- Background Parkinson's disease is a growing concern as the longevity of the world's population steadily increases. Both ageing and Parkinson's disease have an impact on dopamine neurotransmission. It is therefore important to investigate their relative impact on the fronto-striatal reward system. There has been little investigation of reward processing in terms of anticipation and reward outcome in Parkinson's disease. Abnormal responses during reward processing have previously been demonstrated in whole-brain analysis of Parkinson's patients with mild lateralized disease, but the exact impact in regions specific to reward processing is still unknown. Objective Here we aim to investigate the impact of Parkinson's disease on the orbitofrontal ventral striatal reward system in patients with moderate to severe clinical symptoms. Methods We utilized a monetary incentive delay (MID) task in 17 Parkinson's patients who were compared to two control groups stratified by age. The MID paradigm reliably activates the ventral striatum during reward anticipation and the orbitofrontal cortex during reward outcome processing. Results Relative to the two control groups, Parkinson's disease patients had abnormal task related activity during both reward anticipation in the ventral striatum and reward outcome in the orbitofrontal cortex. There were no effects of ageing. Conclusion These findings demonstrate abnormalities in anticipatory as well as reward outcome processing while treated primarily with levodopa. The orbitofrontal dysfunction during reward outcome processing may have specificity in Parkinson's disease, as it has been shown to be relatively unaffected by normal ageing.
- Subjects :
- Male
Levodopa
Parkinson's disease
Population
Prefrontal Cortex
Disease
050105 experimental psychology
Antiparkinson Agents
03 medical and health sciences
Reward system
0302 clinical medicine
Reward
Image Processing, Computer-Assisted
Reaction Time
Orbitofrontal cortex
Humans
Medicine
0501 psychology and cognitive sciences
education
Aged
Motivation
education.field_of_study
business.industry
05 social sciences
Ventral striatum
Parkinson Disease
Middle Aged
medicine.disease
Magnetic Resonance Imaging
Anticipation
Oxygen
Reward processing
medicine.anatomical_structure
Neurology
Female
Neurology (clinical)
Geriatrics and Gerontology
business
Neuroscience
030217 neurology & neurosurgery
psychological phenomena and processes
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 13538020
- Database :
- OpenAIRE
- Journal :
- Parkinsonism & related disorders, 48, 82. Elsevier BV
- Accession number :
- edsair.doi.dedup.....de08ff57a27c972c21254f03092a6541