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Squamous cell carcinoma of the penis: Predicting nodal metastases by histologic grade, pattern of invasion and clinical examination
Squamous cell carcinoma of the penis: Predicting nodal metastases by histologic grade, pattern of invasion and clinical examination
- Source :
- Urologic Oncology: Seminars and Original Investigations. 29:774-781
- Publication Year :
- 2011
- Publisher :
- Elsevier BV, 2011.
-
Abstract
- With a diagnosis of squamous cell carcinoma of the penis, there is still a significant need to define the tumor criteria that allow the disease to be stratified according to the risk of developing lymph node metastases. The histopathology of the primary tumor in 72 consecutive patients with resected squamous cell carcinoma of the penis was reviewed for this study. Tumor tissue was reviewed for (1) histologic grade, (2) invasion pattern, (3) tumor stage, (4) proportion of poorly differentiated tumor cells, (5) invasion depth, (6) proportion of tumor necrosis, (7) angioinvasion, (8) histologic classification, (9) number of lesions, (10) growth pattern, (11) number of mitoses, (12) degree of keratinization, and (13) clinical groin status. It was found that the presence of inguinal lymph node metastases correlated in descending order of frequency with grade G2/G3, clinically positive groin status, reticular invasion, stage pT2/T3, >50% poorly differentiated tumor cells, depth of invasion, and comedolike tumor necrosis. These results revealed that the risk of inguinal lymph node metastasis in penile carcinoma can be predicted on the basis of 3 major factors: histologic grade, pattern of invasion, and clinical groin status.
- Subjects :
- Adult
Male
Pathology
medicine.medical_specialty
Urology
Kaplan-Meier Estimate
Metastasis
Penile Carcinoma
Carcinoma
Humans
Medicine
Neoplasm Invasiveness
Penile Neoplasms
Lymph node
Aged
Neoplasm Staging
Retrospective Studies
Aged, 80 and over
Angioinvasion
Groin
business.industry
Middle Aged
medicine.disease
Immunohistochemistry
Primary tumor
medicine.anatomical_structure
Oncology
Lymphatic Metastasis
Carcinoma, Squamous Cell
Neoplasm Grading
business
Penis
Subjects
Details
- ISSN :
- 10781439
- Volume :
- 29
- Database :
- OpenAIRE
- Journal :
- Urologic Oncology: Seminars and Original Investigations
- Accession number :
- edsair.doi.dedup.....de1fd8ed6016165de79479a8421aba72
- Full Text :
- https://doi.org/10.1016/j.urolonc.2009.10.014