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Squamous cell carcinoma of the penis: Predicting nodal metastases by histologic grade, pattern of invasion and clinical examination

Squamous cell carcinoma of the penis: Predicting nodal metastases by histologic grade, pattern of invasion and clinical examination

Authors :
Ibrahim Alkatout
Axel Hegele
Jürgen Hedderich
Carsten Maik Naumann
Christian Bolenz
K.P. Jünemann
Günter Klöppel
Source :
Urologic Oncology: Seminars and Original Investigations. 29:774-781
Publication Year :
2011
Publisher :
Elsevier BV, 2011.

Abstract

With a diagnosis of squamous cell carcinoma of the penis, there is still a significant need to define the tumor criteria that allow the disease to be stratified according to the risk of developing lymph node metastases. The histopathology of the primary tumor in 72 consecutive patients with resected squamous cell carcinoma of the penis was reviewed for this study. Tumor tissue was reviewed for (1) histologic grade, (2) invasion pattern, (3) tumor stage, (4) proportion of poorly differentiated tumor cells, (5) invasion depth, (6) proportion of tumor necrosis, (7) angioinvasion, (8) histologic classification, (9) number of lesions, (10) growth pattern, (11) number of mitoses, (12) degree of keratinization, and (13) clinical groin status. It was found that the presence of inguinal lymph node metastases correlated in descending order of frequency with grade G2/G3, clinically positive groin status, reticular invasion, stage pT2/T3, >50% poorly differentiated tumor cells, depth of invasion, and comedolike tumor necrosis. These results revealed that the risk of inguinal lymph node metastasis in penile carcinoma can be predicted on the basis of 3 major factors: histologic grade, pattern of invasion, and clinical groin status.

Details

ISSN :
10781439
Volume :
29
Database :
OpenAIRE
Journal :
Urologic Oncology: Seminars and Original Investigations
Accession number :
edsair.doi.dedup.....de1fd8ed6016165de79479a8421aba72
Full Text :
https://doi.org/10.1016/j.urolonc.2009.10.014