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Surgical margins in oral cavity squamous cell carcinoma: Current practices and future directions
- Source :
- The LaryngoscopeBIBLIOGRAPHY. 130(1)
- Publication Year :
- 2018
-
Abstract
- OBJECTIVE To discuss the current available techniques for intraoperative margin assessment in the surgical treatment of oral squamous cell carcinoma (OSCC) through a review of the available literature. METHODS A systematic review was undertaken of the available English literature between 2008 through 2018 regarding surgical margins in OCSS. A total of 893 relevant articles were returned; 144 met criteria for review; and 64 articles were included. RESULTS In this review, we discuss the data surrounding the use of frozen section in OCSS. Additionally, alternative techniques for margin assessment are discussed, including Mohs, molecular analysis, nonfluorescent dyes, fluorescent dyes, autofluorescent imaging, narrow-band imaging, optical coherence tomography, confocal microscopy, high-resolution microendoscopy, and spectroscopy. For each technique, particular emphasis is placed on the local recurrence, disease-free survival, and overall survival rates when available. CONCLUSION This review provides support for the practice of specimen-driven margin assessment when using frozen section analysis to improve the utility of the results. Finally, several alternatives for intraoperative margin assessment currently under investigation, including pathologic, wide-field imaging and narrow-field imaging techniques, are presented. We aim to fuel further investigation into methods for margin assessment that will improve survival for patients with OSCC through a critical analysis of the available techniques. LEVEL OF EVIDENCE NA Laryngoscope, 130:128-138, 2020.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
03 medical and health sciences
0302 clinical medicine
Optical coherence tomography
Margin (machine learning)
medicine
Overall survival
Humans
Basal cell
Oral Cavity Squamous Cell Carcinoma
Surgical treatment
Intraoperative Care
medicine.diagnostic_test
business.industry
Margins of Excision
Evidence-based medicine
Molecular analysis
030104 developmental biology
Otorhinolaryngology
030220 oncology & carcinogenesis
Carcinoma, Squamous Cell
Mouth Neoplasms
Radiology
business
Forecasting
Subjects
Details
- ISSN :
- 15314995
- Volume :
- 130
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- The LaryngoscopeBIBLIOGRAPHY
- Accession number :
- edsair.doi.dedup.....de25485f07eaad5937d628b42ea13b9a