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New neuroprotective effect of lemon integropectin on neuronal cellular model
- Source :
- Antioxidants, Antioxidants 10 (2021). doi:10.3390/antiox10050669, info:cnr-pdr/source/autori:Nuzzo D; Picone P; Giardina C; Scordino M; Mudo G; Pagliaro M; Scurria A; Meneguzzo F; Ilharco LM; Fidalgo A; Alduina R; Presentato A; Ciriminna R; Di Liberto V;/titolo:New neuroprotective effect of lemon integropectin on neuronal cellular model/doi:10.3390%2Fantiox10050669/rivista:Antioxidants/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volume:10, Volume 10, Issue 5, Antioxidants, Vol 10, Iss 669, p 669 (2021)
- Publication Year :
- 2021
- Publisher :
- MDPI AG, 2021.
-
Abstract
- Lemon IntegroPectin obtained via hydrodynamic cavitation of organic lemon processing waste in water shows significant neuroprotective activity in vitro, as first reported in this study investigating the effects of both lemon IntegroPectin and commercial citrus pectin on cell viability, cell morphology, reactive oxygen species (ROS) production, and mitochondria perturbation induced by treatment of neuronal SH-SY5Y human cells with H2O2. Mediated by ROS, including H2O2 and its derivatives, oxidative stress alters numerous cellular processes, such as mitochondrial regulation and cell signaling, propagating cellular injury that leads to incurable neurodegenerative diseases. These results, and the absence of toxicity of this new pectic substance rich in adsorbed flavonoids and terpenes, suggest further studies to investigate its activity in preventing, retarding, or even curing neurological diseases.
- Subjects :
- Cell signaling
antioxidant
Physiology
hesperidin
Antioxidant, Flavonoids, Hesperidin, Mitochondria, Neu-roprotective, Neurological disease, Oxidative stress, Pectin
Clinical Biochemistry
RM1-950
Mitochondrion
Cell morphology
medicine.disease_cause
Biochemistry
Neuroprotection
Article
flavonoids
03 medical and health sciences
0302 clinical medicine
medicine
oxidative stress
Viability assay
neurological disease
Molecular Biology
030304 developmental biology
chemistry.chemical_classification
pectin
neuroprotective
0303 health sciences
Reactive oxygen species
Cell Biology
Cell biology
mitochondria
chemistry
Therapeutics. Pharmacology
Cellular model
030217 neurology & neurosurgery
Oxidative stress
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Antioxidants, Antioxidants 10 (2021). doi:10.3390/antiox10050669, info:cnr-pdr/source/autori:Nuzzo D; Picone P; Giardina C; Scordino M; Mudo G; Pagliaro M; Scurria A; Meneguzzo F; Ilharco LM; Fidalgo A; Alduina R; Presentato A; Ciriminna R; Di Liberto V;/titolo:New neuroprotective effect of lemon integropectin on neuronal cellular model/doi:10.3390%2Fantiox10050669/rivista:Antioxidants/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volume:10, Volume 10, Issue 5, Antioxidants, Vol 10, Iss 669, p 669 (2021)
- Accession number :
- edsair.doi.dedup.....de2649b5d9b78da333b968dcef92c423