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Large-scale genomic analysis shows association between homoplastic genetic variation in Mycobacterium tuberculosis genes and meningeal or pulmonary tuberculosis

Authors :
Ruesen, Carolien
Chaidir, Lidya
van Laarhoven, Arjan
Dian, Sofiati
Ganiem, Ahmad Rizal
Nebenzahl-Guimaraes, Hanna
Huynen, Martijn A
Alisjahbana, Bachti
Dutilh, Bas E
van Crevel, Reinout
Sub Bioinformatics
Theoretical Biology and Bioinformatics
Universidade do Minho
Sub Bioinformatics
Theoretical Biology and Bioinformatics
Source :
BMC Genomics, 19(1). BioMed Central, BMC Genomics, Vol 19, Iss 1, Pp 1-11 (2018), Repositório Científico de Acesso Aberto de Portugal, Repositório Científico de Acesso Aberto de Portugal (RCAAP), instacron:RCAAP, BMC Genomics, 19,, BMC Genomics, 19, pp., BMC Genomics
Publication Year :
2018
Publisher :
Springer Nature, 2018.

Abstract

Meningitis is the most severe manifestation of tuberculosis. It is largely unknown why some people develop pulmonary TB (PTB) and others TB meningitis (TBM); we examined if the genetic background of infecting M. tuberculosis strains may be relevant.<br />This study was supported by the Royal Netherlands Academy of Arts and Sciences (KNAW). [09-PD-14 to RvC]; fellowship from the Netherlands Organization for Health Research and Development (ZonMw) and The Netherlands Foundation for Scientific Research [VIDI grant. 017.106.310 to RvC., and VIDI grant 864.14.004 to BED.]; and Radboud University fellowship [to CR]. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. This study was also supported by the TANDEM (Tuberculosis and Diabetes Mellitus) Grant of the ECFP7 (European Union’s Seventh Framework Programme) under Grant Agreement no. 305279<br />info:eu-repo/semantics/publishedVersion

Subjects

Subjects :
0301 basic medicine
Medicina Básica [Ciências Médicas]
lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4]
Tumours of the digestive tract Radboud Institute for Molecular Life Sciences [Radboudumc 14]
Non-U.S. Gov't
GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries)
Phylogeny
Genetics
Phylogenetic tree
biology
Research Support, Non-U.S. Gov't
Pulmonary tuberculosis
Metabolic Disorders Radboud Institute for Molecular Life Sciences [Radboudumc 6]
Genomics
3. Good health
Phenotype
Tuberculosis, Meningeal
Ciências Médicas::Medicina Básica
Research Article
Biotechnology
Lineage (genetic)
Tuberculosis
lcsh:QH426-470
lcsh:Biotechnology
030106 microbiology
Single-nucleotide polymorphism
macromolecular substances
Research Support
Polymorphism, Single Nucleotide
Mycobacterium tuberculosis
03 medical and health sciences
All institutes and research themes of the Radboud University Medical Center
lcsh:TP248.13-248.65
Genetic variation
medicine
Humans
Homoplasy
Gene
Tuberculosis, Pulmonary
Science & Technology
Computational Biology
Genetic Variation
biology.organism_classification
medicine.disease
Tuberculous meningitis
lcsh:Genetics
030104 developmental biology
lnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4]
Genetic distance
Indonesia
Genes, Bacterial
Whole genome sequencing
Genome, Bacterial

Details

Language :
English
ISSN :
14712164
Database :
OpenAIRE
Journal :
BMC Genomics, 19(1). BioMed Central, BMC Genomics, Vol 19, Iss 1, Pp 1-11 (2018), Repositório Científico de Acesso Aberto de Portugal, Repositório Científico de Acesso Aberto de Portugal (RCAAP), instacron:RCAAP, BMC Genomics, 19,, BMC Genomics, 19, pp., BMC Genomics
Accession number :
edsair.doi.dedup.....de574b966b7cf182d5262dbf7c2763b6

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