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Tumor-secreted products repress B-cell lymphopoiesis in a murine model of breast cancer
- Source :
- European journal of immunology. 46(12)
- Publication Year :
- 2016
-
Abstract
- Growing cancers are known to modify immune responses through suppressive mechanisms manifested within the local tumor microenvironment. Accumulating evidence indicates that secreted tumor products can also influence on distant immunological compartments, including myelopoiesis in the bone marrow. However, it is unknown if a similar effect can occur to regulate B-cell lymphopoiesis in breast cancer. Examining the MMTV-PyMT murine model of breast cancer, we show a complete block in bone marrow B-cell lymphopoiesis, which is dependent on tumor burden. We also observed an increase in the total number of splenic B cells and an elevated frequency of marginal zone B cells. By using in vitro assays of B-cell lymphopoiesis, we show that tumor-secreted molecules directly inhibit B-cell progenitor proliferation and favor maturation. These data demonstrate a profound sensitivity of B-cell lymphopoiesis to the accumulation of ectopically produced molecules during tumor growth in PyMT.
- Subjects :
- 0301 basic medicine
Immunology
Bone Marrow Cells
Breast Neoplasms
Mice, Transgenic
Biology
Lymphocyte Activation
03 medical and health sciences
Mice
Immune system
Cell Line, Tumor
medicine
Tumor Microenvironment
Immunology and Allergy
Animals
Humans
Lymphopoiesis
Antigens, Viral, Tumor
B cell
Cell Proliferation
Tumor microenvironment
B-Lymphocytes
Marginal zone
Tumor Burden
Mice, Inbred C57BL
Haematopoiesis
030104 developmental biology
medicine.anatomical_structure
Mammary Tumor Virus, Mouse
Cancer research
Female
Tumor Escape
Bone marrow
Myelopoiesis
Subjects
Details
- ISSN :
- 15214141
- Volume :
- 46
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- European journal of immunology
- Accession number :
- edsair.doi.dedup.....de6424ab7e629683775a108622c8f8e5