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Differential alterations in resting state functional connectivity associated with depressive symptoms and early life adversity
- Source :
- Brain Sciences, Volume 11, Issue 5, Brain Sciences, Vol 11, Iss 591, p 591 (2021)
- Publication Year :
- 2021
- Publisher :
- MDPI, 2021.
-
Abstract
- Depression and early life adversity (ELA) are associated with aberrant resting state functional connectivity (FC) of the default mode (DMN), salience (SN), and central executive networks (CEN). However, the specific and differential associations of depression and ELA with FC of these networks remain unclear. Applying a dimensional approach, here we analyzed associations of FC between major nodes of the DMN, SN, and CEN with severity of depressive symptoms and ELA defined as childhood abuse and neglect in a sample of 83 healthy and depressed subjects. Depressive symptoms were linked to increased FC within the SN and decreased FC of the SN with the DMN and CEN. Childhood abuse was associated with increased FC within the SN, whereas childhood neglect was associated with decreased FC within the SN and increased FC between the SN and the DMN. Our study thus provides evidence for differential associations of depressive symptoms and ELA with resting state FC and contributes to a clarification of previously contradictory findings. Specific FC abnormalities may underlie specific cognitive and emotional impairments. Future research should link specific clinical symptoms resulting from ELA to FC patterns thereby characterizing depression subtypes with specific neurobiological signatures.
- Subjects :
- media_common.quotation_subject
610 Medicine & health
Neurosciences. Biological psychiatry. Neuropsychiatry
616.8: Neurologie und Krankheiten des Nervensystems
Article
Neglect
03 medical and health sciences
Functional connectivity
0302 clinical medicine
Medicine
Depressive symptoms
Default mode network
Depression (differential diagnoses)
media_common
Resting state fMRI
10093 Institute of Psychology
business.industry
Depression
General Neuroscience
2800 General Neuroscience
Cognition
Early life
030227 psychiatry
10057 Klinik für Konsiliarpsychiatrie und Psychosomatik
10054 Clinic for Psychiatry, Psychotherapy, and Psychosomatics
business
Early life adversity
Neuroscience
030217 neurology & neurosurgery
RC321-571
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Brain Sciences, Volume 11, Issue 5, Brain Sciences, Vol 11, Iss 591, p 591 (2021)
- Accession number :
- edsair.doi.dedup.....de7bcb86c1def293a1764cef661bcd26
- Full Text :
- https://doi.org/10.21256/zhaw-22643