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Unveiling the evolution routes of TEM-type extended-spectrum β-lactamases

Authors :
Qipeng Cheng
Yan Chu Cheung
Edward Wai Chi Chan
Kwok Yin Wong
Sheng Chen
Source :
International Journal of Antimicrobial Agents. 59:106498
Publication Year :
2022
Publisher :
Elsevier BV, 2022.

Abstract

The TEM-1 β-lactamase can only cleave penicillin and the first-generation cephalosporins but it has evolved to become active against second-, third- and fourth-generation drugs. Through sequence analysis of natural TEM variants and those created by mutagenesis experiments, we described two distinct evolution routes of TEM-1 that has generated over 220 enzyme variants. One began with the Gly

Details

ISSN :
09248579
Volume :
59
Database :
OpenAIRE
Journal :
International Journal of Antimicrobial Agents
Accession number :
edsair.doi.dedup.....de849f7ae14dc9b3c1cf0265e16c5abe
Full Text :
https://doi.org/10.1016/j.ijantimicag.2021.106498