Back to Search
Start Over
Unveiling the evolution routes of TEM-type extended-spectrum β-lactamases
- Source :
- International Journal of Antimicrobial Agents. 59:106498
- Publication Year :
- 2022
- Publisher :
- Elsevier BV, 2022.
-
Abstract
- The TEM-1 β-lactamase can only cleave penicillin and the first-generation cephalosporins but it has evolved to become active against second-, third- and fourth-generation drugs. Through sequence analysis of natural TEM variants and those created by mutagenesis experiments, we described two distinct evolution routes of TEM-1 that has generated over 220 enzyme variants. One began with the Gly
Details
- ISSN :
- 09248579
- Volume :
- 59
- Database :
- OpenAIRE
- Journal :
- International Journal of Antimicrobial Agents
- Accession number :
- edsair.doi.dedup.....de849f7ae14dc9b3c1cf0265e16c5abe
- Full Text :
- https://doi.org/10.1016/j.ijantimicag.2021.106498