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Improving Pharmaceutical Innovation By Building A More Comprehensive Database On Drug Development And Use

Improving Pharmaceutical Innovation By Building A More Comprehensive Database On Drug Development And Use

Authors :
Céline Audibert
Gregory W. Daniel
Alexis Caze
Mark McClellan
Morgan H. Romine
Jonathan Leff
Source :
Health Affairs. 34:319-327
Publication Year :
2015
Publisher :
Health Affairs (Project Hope), 2015.

Abstract

New drugs and biologics have had a tremendous impact on the treatment of many diseases. However, available measures suggest that pharmaceutical innovation has remained relatively flat, despite substantial growth in research and development spending. We review recent literature on pharmaceutical innovation to identify limitations in measuring and assessing innovation, and we describe the framework and collaborative approach we are using to develop more comprehensive, publicly available metrics for innovation. Our research teams at the Brookings Institution and Deerfield Institute are collaborating with experts from multiple areas of drug development and regulatory review to identify and collect comprehensive data elements related to key development and regulatory characteristics for each new molecular entity approved over the past several decades in the United States and the European Union. Subsequent phases of our effort will add data on downstream product use and patient outcomes and will also include drugs that have failed or been abandoned in development. Such a database will enable researchers to better analyze the drivers of drug innovation, trends in the output of new medicines, and the effect of policy efforts designed to improve innovation.

Details

ISSN :
15445208 and 02782715
Volume :
34
Database :
OpenAIRE
Journal :
Health Affairs
Accession number :
edsair.doi.dedup.....de8cb1258f73ffedbdc58c7c61b7c4a4
Full Text :
https://doi.org/10.1377/hlthaff.2014.1019