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Calcium signaling in physiology and pathophysiology
- Source :
- Acta Pharmacologica Sinica. 27:767-772
- Publication Year :
- 2006
- Publisher :
- Springer Science and Business Media LLC, 2006.
-
Abstract
- Calcium ions are the most ubiquitous and pluripotent cellular signaling molecules that control a wide variety of cellular processes. The calcium signaling system is represented by a relatively limited number of highly conserved transporters and channels, which execute Ca2+ movements across biological membranes and by many thousands of Ca2+-sensitive effectors. Molecular cascades, responsible for the generation of calcium signals, are tightly controlled by Ca2+ ions themselves and by genetic factors, which tune the expression of different Ca2+-handling molecules according to adaptational requirements. Ca2+ ions determine normal physiological reactions and the development of many pathological processes.
- Subjects :
- Pharmacology
Calcium metabolism
Cell signaling
Voltage-dependent calcium channel
Effector
chemistry.chemical_element
Physiology
Biological membrane
General Medicine
Biology
Calcium
chemistry
Neoplasms
Animals
Humans
Pharmacology (medical)
Calcium Channels
Calcium Signaling
Signal transduction
Signal Transduction
Calcium signaling
Subjects
Details
- ISSN :
- 17457254 and 16714083
- Volume :
- 27
- Database :
- OpenAIRE
- Journal :
- Acta Pharmacologica Sinica
- Accession number :
- edsair.doi.dedup.....de90d306c7455af5d0ec82a9717a7b7c