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Antibacterial and antibiotic modifying activity evaluation of ruminants' body fat used as zootherapeutics in ethnoveterinary practices in Northeast Brazil
- Source :
- Journal of ethnopharmacology. 233
- Publication Year :
- 2018
-
Abstract
- Ethnopharmacological relevance Northeast Brazilian ethnoveterinary studies associated with the medicinal use of zootherapies have shown that ruminants’ body fat such as sheep (Ovis aries), goats (Capra hircus) and cows (Bos taurus) are used in diseases affecting domestic animals. Aim of the study The objective of this study was to evaluate the antibacterial activity of the fixed oils from these ruminants in isolation and in association with antibiotics. Results Ovis aries (OFOA), Capra hircus (OFCH) and Bos taurus (OFBT) fixed oils were extracted using a Soxhlet apparatus with hexane as the solvent. Through the use of gas chromatography coupled to mass spectrometry (GC-MS) the methyl esters from the ruminants’ fixed oils were obtained and the fatty acids present in these oils were indirectly determined. The OFOA, OFCH and OFBT antibacterial and antibiotic modifying activities against standard and multi-resistant bacterial strains were carried out using the broth microdilution test. The fixed oils from these species did not present antibacterial activity when tested in isolation, obtaining Minimal Inhibitory Concentration (MICs) values ≥ 1024 μg/mL. However, when associated with antibiotics, OFBT and OFCH showed a synergistic activity for the Amicacin, Amoxicillin, Norfloxacin and Oxytetracycline antibiotics. Conclusion The OFOA promoted a synergistic action for the same antibiotics with the exception of Norfloxacin.
- Subjects :
- Male
medicine.drug_class
Antibiotics
Oxytetracycline
Microbial Sensitivity Tests
03 medical and health sciences
Minimum inhibitory concentration
0302 clinical medicine
Drug Discovery
medicine
Capra hircus
Animals
Ovis
Norfloxacin
030304 developmental biology
Pharmacology
0303 health sciences
Sheep
Traditional medicine
biology
Bacteria
Goats
Broth microdilution
Fatty Acids
biology.organism_classification
Anti-Bacterial Agents
Adipose Tissue
030220 oncology & carcinogenesis
Cattle
Female
Antibacterial activity
Oils
medicine.drug
Subjects
Details
- ISSN :
- 18727573
- Volume :
- 233
- Database :
- OpenAIRE
- Journal :
- Journal of ethnopharmacology
- Accession number :
- edsair.doi.dedup.....de98254aa376d8386cf25409e2fd16be