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Mucocutaneous Manifestations in Autoimmune Gastritis: A Prospective Case-Control Study
- Source :
- Am J Gastroenterol
- Publication Year :
- 2021
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2021.
-
Abstract
- Introduction Autoimmune gastritis (AIG) is associated with nutritional deficiencies, autoimmune diseases, and gastric malignancies. The aims of the study were to test the hypothesis that mucocutaneous (MC) manifestations occur more often in patients with vs without AIG and to delineate patterns of MC manifestations in AIG. Methods A single-center, prospective 2:1 case-control study was conducted. Cases were patients with the diagnosis of AIG based on consistent serologic and histologic findings. Controls had a normal gastric biopsy. MC manifestations were independently evaluated by 3 experienced dermatologists. We conducted a multivariable logistic regression model adjusted for age, sex, Helicobacter pylori, tobacco use, and alcohol consumption to estimate the association between AIG (vs no AIG) and MC manifestations (adjusted odds ratio; 95% confidence interval). Results We prospectively enrolled 60 cases and 30 controls (mean age 53.5 ± 15.8 vs 53.4 ± 14.5 years; 75% vs 73.3% women). The pooled prevalence of MC immune-mediated diseases was higher in patients with vs without AIG (66.7% vs 23.3%; adjusted odds ratio 12.01 [95% confidence interval: 3.51-41.13]). In patients with AIG, seropositive vs seronegative anti-intrinsic factor antibodies more often had concomitant immunological diseases with MC manifestations (100% vs 58.5%; P = 0.016). The most common MC immune-mediated diseases in AIG were Sjogren syndrome (n = 5, 8.3%), alopecia areata (n = 5, 8.3%), and vitiligo (n = 4, 6.7%). Nutritional deficiency-related MC findings, mainly xerosis, lingual, and nail disorders, were also more common in AIG. Discussion This is the first comparative study specifically designed to evaluate MC manifestations in AIG. We demonstrated that AIG is more frequently associated with both immune- and nutritional deficiency-related MC manifestations, which might have both diagnostic and therapeutic clinical implications.
- Subjects :
- Male
medicine.medical_specialty
Autoimmune Gastritis
Biopsy
Mucocutaneous zone
Autoimmunity
Vitiligo
Gastroenterology
Article
Parietal Cells, Gastric
Internal medicine
medicine
Humans
Endoscopy, Digestive System
Prospective Studies
Autoantibodies
Hepatology
biology
business.industry
Stomach
Case-control study
Odds ratio
Middle Aged
Alopecia areata
Helicobacter pylori
medicine.disease
biology.organism_classification
Confidence interval
Diabetes Mellitus, Type 1
Case-Control Studies
Gastritis
Female
business
Follow-Up Studies
Subjects
Details
- ISSN :
- 15720241 and 00029270
- Volume :
- 116
- Database :
- OpenAIRE
- Journal :
- American Journal of Gastroenterology
- Accession number :
- edsair.doi.dedup.....deb1174bd4b0bf947b8b7600bb757d37