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Association of DRD2 and DRD3 polymorphisms with Parkinson's disease in a multiethnic consortium
- Source :
- Journal of the Neurological Sciences. 307:22-29
- Publication Year :
- 2011
- Publisher :
- Elsevier BV, 2011.
-
Abstract
- Objective To examine genetic associations of polymorphisms in the dopamine receptor D2 ( DRD2 ) and D3 ( DRD3 ) genes with risk of Parkinson's disease (PD). Methods The study included 1325 newly diagnosed patients with PD and 1735 controls from a consortium of five North American case–control studies. We collected risk factor information by in-person or telephone interview. Six DRD2 and two DRD3 polymorphisms were genotyped using a common laboratory. Odds ratios were estimated using logistic regression. Results Among non-Hispanic whites, homozygous carriers of Taq1A DRD2 (rs1800497) polymorphism had an increased risk of PD compared to homozygous wildtype carriers (OR = 1.5, 95% CI 1.0–2.3). In contrast, the direction of association for Taq1A polymorphism was opposite for African–Americans, showing an inverse association with PD risk (OR = 0.10, 95% CI 0.2–0.7). Among white Hispanics who carried two alleles, the Ser9Gly DRD3 (rs6280) polymorphism was associated with a decreased risk of PD (OR = 0.4, 95% CI 0.2–0.8). The inverse association of smoking with PD risk was not modified by any of the DRD2 or DRD3 polymorphisms. Conclusions DRD2 polymorphisms are unlikely to be true disease-causing variants; however, three DRD2 polymorphisms (including Taq1A) may be in linkage disequilibrium with possible disease associated variants in the DRD2-ANKK1-NCAM1-TTC12 gene cluster.
- Subjects :
- Male
Linkage disequilibrium
Pathology
medicine.medical_specialty
Inverse Association
Genotype
Risk Assessment
White People
Article
Polymorphism (computer science)
Internal medicine
Epidemiology
Humans
Medicine
Genetic Predisposition to Disease
Allele
Risk factor
Aged
Polymorphism, Genetic
Receptors, Dopamine D2
business.industry
Genetic Carrier Screening
Receptors, Dopamine D3
Case-control study
Parkinson Disease
Hispanic or Latino
Odds ratio
Middle Aged
Black or African American
Neurology
Case-Control Studies
Multigene Family
North America
Female
Neurology (clinical)
business
Subjects
Details
- ISSN :
- 0022510X
- Volume :
- 307
- Database :
- OpenAIRE
- Journal :
- Journal of the Neurological Sciences
- Accession number :
- edsair.doi.dedup.....dec501102ace039b6e6882fbd97b909b