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Lack of Antibodies to SARS-CoV-2 among Blood Donors during COVID-19 Lockdown: A Study from Saudi Arabia
- Source :
- Healthcare, Volume 9, Issue 1, Healthcare, Vol 9, Iss 51, p 51 (2021)
- Publication Year :
- 2021
- Publisher :
- MDPI AG, 2021.
-
Abstract
- In response to the coronavirus disease 2019 (COVID-19), Saudi Arabia have imposed timely restrictions to minimize the infection spread, lower the risk for vulnerable groups, and reduce the pressure on healthcare services. The effectiveness of these measures has not been assessed comprehensively and, thereby, remains uncertain. Besides monitoring the number of COVID-19 cases diagnosed by molecular assays, the seroprevalence can serve as an indicator for the incidence rate among the general population. This study aimed to evaluate seroprevalence status of all healthy blood donors who attended one of the main largest hospital located in the western region of Saudi Arabia from 1 January to 31 May 2020. The study period covered two months prior to reporting the first COVID-19 case in the country on 2 March 2020. Importantly, it covered the period when &ldquo<br />lock-down type&rdquo<br />measures have been enforced. Samples were subjected to in-house enzyme-linked immunosorbent assay (ELISA), chemiluminescence immunoassay (CLIA), and microneutralization (MN). The sero statuses of all samples were confirmed negative, demonstrating the lack of antibodies to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) among blood donors during COVID-19 lockdown period. This study supports the hypothesis that COVID-19 restrictions have potential for limiting the extent of the infection.
- Subjects :
- 2019-20 coronavirus outbreak
medicine.medical_specialty
Coronavirus disease 2019 (COVID-19)
Leadership and Management
Chemiluminescence immunoassay
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Population
Saudi Arabia
lcsh:Medicine
Health Informatics
Article
lockdown
03 medical and health sciences
0302 clinical medicine
Health Information Management
Internal medicine
antibodies
Medicine
Seroprevalence
030212 general & internal medicine
education
030304 developmental biology
0303 health sciences
education.field_of_study
seroprevalence
biology
SARS-CoV-2
business.industry
Health Policy
lcsh:R
COVID-19
Limiting
biology.protein
blood donors
ELISA
Antibody
business
Subjects
Details
- ISSN :
- 22279032
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- Healthcare
- Accession number :
- edsair.doi.dedup.....dec58562e92ef25939c8f46918018c28