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Synthesis and biological evaluation of asymmetric gramicidin S analogues containing modified d-phenylalanine residues
- Source :
- Bioorganic & Medicinal Chemistry, 17(17), 6318-6328. PERGAMON-ELSEVIER SCIENCE LTD
- Publication Year :
- 2009
- Publisher :
- Elsevier BV, 2009.
-
Abstract
- The synthesis of new analogues of the cationic antimicrobial peptide gramicidin S, having a modified D-phenylalanine residue, their antibacterial properties against several Gram positive and negative strains, as well as their hemolytic activity is reported. (C) 2009 Elsevier Ltd. All rights reserved.
- Subjects :
- Erythrocytes
Anti-microbial peptides
Stereochemistry
Phenylalanine
Clinical Biochemistry
Antimicrobial peptides
Pharmaceutical Science
Peptide
Microbial Sensitivity Tests
Gramicidin S
Hemolysis
Biochemistry
Chemical synthesis
Residue (chemistry)
chemistry.chemical_compound
DIFFRACTION DATA
Gramicidin S derivatives
Drug Discovery
Humans
Biological profile
AMINO-ACIDS
Molecular Biology
Antibacterial agent
chemistry.chemical_classification
Organic Chemistry
Gramicidin
Biological activity
ANTIMICROBIAL PEPTIDES
Cyclic peptide
Anti-Bacterial Agents
CONFORMATION
MODEL
chemistry
SOLID-PHASE
Molecular Medicine
Subjects
Details
- ISSN :
- 09680896
- Volume :
- 17
- Database :
- OpenAIRE
- Journal :
- Bioorganic & Medicinal Chemistry
- Accession number :
- edsair.doi.dedup.....decd45525d1fe99ce1e3c2371484b0c7
- Full Text :
- https://doi.org/10.1016/j.bmc.2009.07.042