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Analgesic efficacy of postoperative bilateral, ultrasound-guided, posterior transversus abdominis plane block for laparoscopic colorectal cancer surgery: a randomized, prospective, controlled study
- Source :
- BMC Anesthesiology, BMC Anesthesiology, Vol 21, Iss 1, Pp 1-10 (2021)
- Publication Year :
- 2021
- Publisher :
- BioMed Central, 2021.
-
Abstract
- Background We assessed whether a postoperative bilateral, ultrasound-guided, posterior transversus abdominis plane (TAP) block could reduce 24 h rescue tramadol requirement compared with placebo in patients undergoing elective laparoscopic colorectal cancer surgery. Methods Patients scheduled to undergo elective laparoscopic surgery following the diagnosis of colorectal cancer were included in this study and randomized into Group and Group Control. The patients received a postoperative bilateral, ultrasound-guided, posterior TAP block in either 20 mL of 0.5% ropivacaine (Group TAP) per side or an equivalent volume of normal saline (Group Control). The primary outcome was the cumulative consumption of rescue tramadol within 24 h after the surgery. Secondary endpoints included (1) resting and movement numerical rating scale (NRS) pain scores at 2, 4, 6, 12, 24, 48, and 72 h; (2) incidences of related side effects; (3) time to the first request for rescue tramadol; (4) patient satisfaction regarding postoperative analgesia; (5) time to restoration of intestinal function; (6) time to mobilization; and (7) the length of hospital stay. Results In total, 92 patients were randomized, and 82 patients completed the analysis. The total rescue tramadol requirement (median [interquartile range]) within the first 24 h was lower in Group TAP (0 [0, 87.5] mg) than in Group Control (100 [100, 200] mg), P P P = 0.002), which was similar on days 2 (P = 0.702) and 3 (P = 0.551), compared with the Group Control. A few incidences of opioid-related side effects (P Conclusions A postoperative bilateral, ultrasound-guided, posterior TAP block resulted in better pain management and a faster recovery in patients undergoing laparoscopic colorectal cancer surgery, without adverse effects. Trial registration The study was registered at http://www.chictr.org.cn (ChiCTR-IPR-17012650; Sep 12, 2017).
- Subjects :
- Laparoscopic surgery
Male
medicine.medical_treatment
Analgesic
Placebo
lcsh:RD78.3-87.3
03 medical and health sciences
0302 clinical medicine
Double-Blind Method
030202 anesthesiology
Transversus Abdominis Plane Block
Interquartile range
Analgesia technique
medicine
Humans
Ropivacaine
030212 general & internal medicine
Prospective Studies
Anesthetics, Local
Adverse effect
Tramadol
Ultrasonography, Interventional
Postoperative Care
Pain, Postoperative
business.industry
Nerve Block
Middle Aged
Drug Utilization
Analgesics, Opioid
Anesthesiology and Pain Medicine
lcsh:Anesthesiology
Anesthesia
Colorectal cancer surgery
Female
Laparoscopy
business
Colorectal Neoplasms
TAP block
medicine.drug
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 14712253
- Volume :
- 21
- Database :
- OpenAIRE
- Journal :
- BMC Anesthesiology
- Accession number :
- edsair.doi.dedup.....ded26252809ec84b537fcc469769b213