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An initial dosing method for teicoplanin based on the area under the serum concentration time curve required for MRSA eradication
- Source :
- Journal of Infection and Chemotherapy. 17:297-300
- Publication Year :
- 2011
- Publisher :
- Elsevier BV, 2011.
-
Abstract
- Teicoplanin is a glycopeptide antibacterial agent that has a long serum half-life and therefore takes time to achieve steady-state conditions. An appropriate initial dosing is needed for teicoplanin to promptly reach an effective serum trough concentration. However, little information is available on tailoring the initial dosing for patients with various characteristics. The objective of this study was to develop a nomogram for determining teicoplanin initial dose to promptly reach an effective trough concentration (≥ 13 μg/mL). A logistic regression analysis was performed to test whether the area under the concentration time curve (AUC) is a significant predictor of microbiological response (persistence 0; eradication 1). The study included 24 adult patients with methicillin-resistant Staphylococcus aureus infections [minimal inhibitory concentration (MIC) for the isolates was
- Subjects :
- Adult
Methicillin-Resistant Staphylococcus aureus
Microbiology (medical)
medicine.medical_specialty
Population
Urology
Renal function
Pharmacology
Loading dose
Pharmacokinetics
medicine
Humans
Pharmacology (medical)
Trough Concentration
education
Antibacterial agent
education.field_of_study
medicine.diagnostic_test
Teicoplanin
business.industry
Staphylococcal Infections
Anti-Bacterial Agents
Nomograms
Infectious Diseases
Therapeutic drug monitoring
Area Under Curve
Drug Monitoring
business
Software
medicine.drug
Subjects
Details
- ISSN :
- 1341321X
- Volume :
- 17
- Database :
- OpenAIRE
- Journal :
- Journal of Infection and Chemotherapy
- Accession number :
- edsair.doi.dedup.....def77d2ce737c509524476a9ddfa06ce