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Cornus sanguinea Fruits: a Source of Antioxidant and Antisenescence Compounds Acting on Aged Human Dermal and Gingival Fibroblasts
- Source :
- Planta medica. 87(10-11)
- Publication Year :
- 2021
-
Abstract
- Five new compounds, a flavonol glycoside ( 1), a megastigmane ( 2), 2 cyclohexylethanoids ( 3, 4), and a phenylethanoid derivative ( 5), together with 15 known compounds ( 6– 20) including flavonoid glycosides, cyclohexylethanoids, and phenolic compounds, have been isolated from Cornus sanguinea drupes. All the structures have been determined by 1D and 2D NMR spectroscopic analysis and mass spectrometry data. The antioxidant capability of the most representative isolated compounds was evaluated in the hydrogen peroxide (H2O2)-induced premature cellular senescence model of human dermal and gingival fibroblasts. Several derivatives counteracted the increase of reactive oxigen species (ROS) production in both cellular models. Among the most promising, compounds 8, 14, and 20 were able to counteract cell senescence, decreasing the expression of p21 and p53. Furthermore, compound 14 decreased the expression of inflammatory cytokines (IL-6) in both cell models and counteracted the decrease of collagen expression induced by the H2O2 in dermal human fibroblasts. These data highlight the anti-aging properties of several isolated compounds from C. sanguinea drupes, supporting its possible use in the cure of skin or periodontitis lesions.
- Subjects :
- Senescence
Antioxidant
antioxidant
medicine.medical_treatment
Cell
Pharmaceutical Science
Cornaceae
Antioxidants
Analytical Chemistry
Proinflammatory cytokine
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Cornus
Drug Discovery
medicine
Humans
cyclohexylethanoids
Hydrogen peroxide
030304 developmental biology
Pharmacology
Periodontitis
chemistry.chemical_classification
0303 health sciences
human fibroblasts
Organic Chemistry
Glycoside
Phenylethanoid
Cornus sanguinea
Hydrogen Peroxide
Fibroblasts
medicine.disease
medicine.anatomical_structure
Complementary and alternative medicine
chemistry
Biochemistry
030220 oncology & carcinogenesis
Fruit
Molecular Medicine
Cornus sanguinea, Cornaceae, cyclohexylethanoids, flavonol glycosides, antioxidant, human fibroblasts
flavonol glycosides
Subjects
Details
- ISSN :
- 14390221
- Volume :
- 87
- Issue :
- 10-11
- Database :
- OpenAIRE
- Journal :
- Planta medica
- Accession number :
- edsair.doi.dedup.....df0f0613e66fab41ffe018e098aa757c