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Analysis of the Hepatic Functional Reserve, Portal Hypertension, and Prognosis of Patients With Human Immunodeficiency Virus/Hepatitis C Virus Coinfection Through Contaminated Blood Products in Japan
- Source :
- Transplantation Proceedings. 46(3):736-738
- Publication Year :
- 2014
- Publisher :
- Elsevier USA, 2014.
-
Abstract
- Background As the survival of human immunodeficiency virus (HIV)-infected individuals has improved due to the widespread use of antiretroviral therapy, the mortality rate due to hepatitis C virus (HCV)-related liver disease has increased in HIV/HCV-coinfected patients. Aim The aims of this study were to establish the appropriate therapeutic strategy for HIV/HCV-coinfected patients by evaluating the liver function, including the hepatic functional reserve and portal hypertension, and to investigate the prognosis of HIV/HCV-coinfected patients in Japan. Patients and Methods In addition to regular liver function tests, the hepatic functional reserve of 41 patients with HIV/HCV coinfection was evaluated using the indocyanine green retention rate and liver galactosyl serum albumin-scintigraphy. The data for 146 patients with HIV/HCV coinfection through blood products were extracted from 4 major HIV centers in Japan. In addition to liver function tests, the platelet counts (PLT) were evaluated as a marker of portal hypertension. Results In spite of the relatively preserved general liver function test results, approximately 40% of the HIV/HCV-coinfected patients had an impaired hepatic functional reserve. In addition, while the albumin and bilirubin levels were normal, the PLT was<br />Transplantation Proceedings, 46(3), pp.736-738; 2014
- Subjects :
- medicine.medical_specialty
medicine.medical_treatment
Hepatitis C virus
contaminated blood products
HIV Infections
Liver transplantation
medicine.disease_cause
Gastroenterology
Liver disease
Japan
Internal medicine
hemophilia
Hypertension, Portal
medicine
Blood-Borne Pathogens
Humans
Transplantation
medicine.diagnostic_test
liver transplantation
business.industry
Mortality rate
Transfusion Reaction
virus diseases
highly active antiretroviral therapy
medicine.disease
Prognosis
Hepatitis C
Liver
non-cirrhotic portal hypertension
Immunology
Coinfection
Portal hypertension
Surgery
Liver function
Liver function tests
business
Subjects
Details
- Language :
- Japanese
- ISSN :
- 00411345
- Volume :
- 46
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Transplantation Proceedings
- Accession number :
- edsair.doi.dedup.....df17e82a9ae6347678ac014cc6752cbd