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Hyaluronan deposition and co-localization with inflammatory cells and collagen in a murine model of fungal allergic asthma
Hyaluronan deposition and co-localization with inflammatory cells and collagen in a murine model of fungal allergic asthma
- Source :
- Inflammation Research. 63:475-484
- Publication Year :
- 2014
- Publisher :
- Springer Science and Business Media LLC, 2014.
-
Abstract
- Allergic asthma is a chronic inflammatory disease of the airways characterized by excessive inflammation and remodeling of the extracellular matrix (ECM) and associated cells of the airway wall. Under inflammatory conditions, hyaluronan (HA), a major component of the ECM, undergoes dynamic changes, which may in turn affect the recruitment and activation of inflammatory cells leading to acute and chronic immunopathology of allergic asthma.In the present study, we measured the changes in HA levels generated at sites of inflammation, and examined its effect on inflammatory responses and collagen deposition in an Aspergillus fumigatus murine inhalational model of allergic asthma.We found that HA levels are elevated in allergic animals and that the increase correlated with the influx of inflammatory cells 5 days after the second allergen challenge. This increase in HA levels appeared largely due to upregulation of hyaluronidase-1 (HYAL1) and hyaluronidase-2 (HYAL2). Furthermore, HA co-localizes with areas of new collagen synthesis and deposition.Overall, our findings contribute to the growing literature that focuses on the components of ECM as inflammatory mediators rather than mere structural support products. The evidence of HA localization in fungal allergic asthma provides the impetus to study HA more closely with allergic leukocytes in murine models. Further studies examining HA's role in mediating cellular responses may help to develop targets for treatment in patients with severe asthma due to fungal sensitization.
- Subjects :
- Allergy
Immunology
Inflammation
Immunoglobulin E
Article
Extracellular matrix
chemistry.chemical_compound
Immunopathology
Hyaluronic acid
Animals
Medicine
Hyaluronic Acid
Lung
Asthma
Pharmacology
biology
business.industry
Aspergillus fumigatus
Allergens
medicine.disease
Extracellular Matrix
respiratory tract diseases
Mice, Inbred C57BL
Disease Models, Animal
medicine.anatomical_structure
chemistry
biology.protein
Collagen
Bronchial Hyperreactivity
medicine.symptom
business
Bronchoalveolar Lavage Fluid
Subjects
Details
- ISSN :
- 1420908X and 10233830
- Volume :
- 63
- Database :
- OpenAIRE
- Journal :
- Inflammation Research
- Accession number :
- edsair.doi.dedup.....df269c741ad4d1055d059ff0d37bb5c4
- Full Text :
- https://doi.org/10.1007/s00011-014-0719-3