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Estimating the proportion of variation in susceptibility to schizophrenia captured by common SNPs
- Source :
- Nature genetics
- Publication Year :
- 2012
-
Abstract
- Schizophrenia is a complex disorder caused by both genetic and environmental factors. Using 9,087 affected individuals, 12,171 controls and 915,354 imputed SNPs from the Schizophrenia Psychiatric Genome-Wide Association Study (GWAS) Consortium (PGC-SCZ), we estimate that 23% (s.e. = 1%) of variation in liability to schizophrenia is captured by SNPs. We show that a substantial proportion of this variation must be the result of common causal variants, that the variance explained by each chromosome is linearly related to its length (r = 0.89, P = 2.6 x 10(-8)), that the genetic basis of schizophrenia is the same in males and females, and that a disproportionate proportion of variation is attributable to a set of 2,725 genes expressed in the central nervous system (CNS; P = 7.6 x 10(-8)). These results are consistent with a polygenic genetic architecture and imply more individual SNP associations will be detected for this disease as sample size increases. Refereed/Peer-reviewed
- Subjects :
- Central Nervous System
Male
Multifactorial Inheritance
SNP
Single-nucleotide polymorphism
Genome-wide association study
Biology
heritability
genomic variance
Polymorphism, Single Nucleotide
Article
03 medical and health sciences
0302 clinical medicine
Polymorphism (computer science)
Genetic variation
Genetics
medicine
GWAS
Chromosomes, Human
Humans
Computer Simulation
Genetic Predisposition to Disease
Human height
030304 developmental biology
Genetics & Heredity
0303 health sciences
Analysis of Variance
Likelihood Functions
Models, Genetic
Genetic Variation
Molecular Sequence Annotation
medicine.disease
Explained variation
schizophrenia
multiple rare alleles
Schizophrenia
missing heritability
Linear Models
disease genetics
Female
Analysis of variance
030217 neurology & neurosurgery
SNPs
Genome-Wide Association Study
Subjects
Details
- Language :
- English
- ISSN :
- 15461718 and 10614036
- Volume :
- 44
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Nature genetics
- Accession number :
- edsair.doi.dedup.....df27f78ff52197ed99fa73b46a6a9a5e