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Performance of the FreeStyle Libre Flash glucose monitoring system in patients with type 1 and 2 diabetes mellitus

Authors :
S Abbes
Mireille A Edens
Henk J. G. Bilo
Marion J Fokkert
D de Jong
P. van Dijk
Robbert J. Slingerland
Lifestyle Medicine (LM)
Source :
BMJ Open Diabetes Research & Care, 5(1):e000320. BMJ PUBLISHING GROUP, BMJ Open Diabetes Research & Care
Publication Year :
2017
Publisher :
BMJ PUBLISHING GROUP, 2017.

Abstract

OBJECTIVE: To evaluate the performance of the FreeStyle Libre Flash continuous glucose monitoring (FSL-CGM) system against established central laboratory methods.RESEARCH DESIGN AND METHODS: 20 subjects (8 type 1 diabetes mellitus, 12 type 2 diabetes mellitus) were analyzed. FSL-CGM sensor measurements (inserted in arm and abdomen) were compared with capillary blood glucose results analyzed with StatStrip as semigold standard. The glucose response after a standardized oral glucose load was measured by FSL-CGM and capillary samples analyzed by perchloric acid hexokinase (PCA-HK) method, StatStrip and FSL test strip (FSLC), and a commonly used CGM system (iPro2).RESULTS: FSL-CGM arm sensor readings showed 85.5% of paired readings falling within Clarke Error Grid (ISO 15197:2013) zone A when compared with StatStrip. For FSL-CGM abdomen and FSLC, these percentages were 64% and 98%, respectively. The overall correlation of FSL-CGM in the arm and the StatStrip indicates a performance with lower results with the FSL-CGM in the arm than expected based on the StatStrip in the lower glucose ranges, and higher results than expected in the higher ranges. Following a standardized glucose load, a slower rise in glucose level was observed for FSL-CGM arm as compared with PCA-HK, StatStrip, FSLC, and iPro2 during the first 45-60 min after glucose load ingestion.CONCLUSIONS: Certain matters need attention while using the FSL-CGM in daily life including the observed lower values in the lower ranges, and the underestimation of the effect of a meal on glucose response. These effects of such deviations can partly be overcome by optimizing the available user instructions.TRIAL REGISTRATION NUMBER: TC5348; results.

Details

Language :
English
ISSN :
20524897
Volume :
5
Issue :
1
Database :
OpenAIRE
Journal :
BMJ Open Diabetes Research & Care
Accession number :
edsair.doi.dedup.....df2fda8efce5dec0b9c99eb662bf36b9