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Experimental and computational studies on the binding of diazinon to human serum albumin

Authors :
Komail Sadrjavadi
Amin Nowroozi
Setareh Samadi
Mohammad Reza Ashrafi-Kooshk
Fataneh Jafari
Mohsen Shahlaei
Sajad Moradi
Source :
Journal of biomolecular structuredynamics. 36(6)
Publication Year :
2017

Abstract

In the present research, the binding properties of diazinon (DZN), as an organophosphorus herbicide, to human serum albumin (HSA) were investigated using combination of spectroscopic, electrochemistry, and molecular modeling techniques. Changes in the UV-Vis and FT-IR spectra were observed upon ligand binding along with a significant degree of tryptophan fluorescence quenching on complex formation. The obtained results from spectroscopic and electrochemistry experiments along with the computational studies suggest that DZN binds to residues located in subdomains IIA of HSA with binding constant about 1410.9 M

Details

ISSN :
15380254
Volume :
36
Issue :
6
Database :
OpenAIRE
Journal :
Journal of biomolecular structuredynamics
Accession number :
edsair.doi.dedup.....df316511c9cdbda30b5504b9b7bb4baf