Back to Search
Start Over
The effects of acute incremental hypocapnia on the magnitude of neurovascular coupling in healthy participants
- Source :
- Physiological Reports, Physiological Reports, Vol 9, Iss 15, Pp n/a-n/a (2021)
- Publication Year :
- 2021
- Publisher :
- Wiley, 2021.
-
Abstract
- The high metabolic demand of cerebral tissue requires that local perfusion is tightly coupled with local metabolic rate (neurovascular coupling; NVC). During chronic altitude exposure, where individuals are exposed to the antagonistic cerebrovascular effects of hypoxia and hypocapnia, pH is maintained through renal compensation and NVC remains stable. However, the potential independent effect of acute hypocapnia and respiratory alkalosis on NVC remains to be determined. We hypothesized that acute steady‐state hypocapnia via voluntary hyperventilation would attenuate the magnitude of NVC. We recruited 17 healthy participants and insonated the posterior cerebral artery (PCA) with transcranial Doppler ultrasound. NVC was elicited using a standardized strobe light stimulus (6 Hz; 5 × 30 s on/off) where absolute delta responses from baseline (BL) in peak, mean, and total area under the curve (tAUC) were quantified. From a BL end‐tidal (PET)CO2 level of 36.7 ± 3.2 Torr, participants were coached to hyperventilate to reach steady‐state hypocapnic steps of Δ‐5 Torr (31.6 ± 3.9) and Δ‐10 Torr (26.0 ± 4.0; p<br />We assessed the NVC response to a visual stimulus, under conditions of normocapnia and two steps of hypocapnia via voluntary hyperventilation.
- Subjects :
- Adult
Male
medicine.medical_specialty
Ultrasonography, Doppler, Transcranial
Physiology
neurovascular coupling
Posterior cerebral artery
03 medical and health sciences
0302 clinical medicine
Hypocapnia
Physiology (medical)
Internal medicine
medicine.artery
Hyperventilation
QP1-981
Humans
Medicine
respiratory alkalosis
030304 developmental biology
0303 health sciences
business.industry
Original Articles
Carbon Dioxide
Hypoxia (medical)
medicine.disease
Healthy Volunteers
Transcranial Doppler
Cerebrovascular Circulation
Respiratory alkalosis
Cardiology
Original Article
Female
medicine.symptom
Renal compensation
business
Perfusion
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 2051817X
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- Physiological Reports
- Accession number :
- edsair.doi.dedup.....df48c94ab63879008ec12d4f7de84e95