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Decreased numbers of metachromatic cells in nasal swabs in Japanese cedar pollinosis following sublingual immunotherapy
- Source :
- Immunity, Inflammation and Disease, Immunity, Inflammation and Disease, Vol 8, Iss 3, Pp 333-341 (2020)
- Publication Year :
- 2020
- Publisher :
- Wiley, 2020.
-
Abstract
- Background and Objective Nasal symptoms were reduced following allergenāspecific sublingual immunotherapy (SLIT) for allergic rhinitis. The mechanisms underlying the effectiveness of SLIT for Japanese cedar pollinosis are poorly understood. We studied changes in the numbers of metachromatic cells, eosinophils, and neutrophils following SLIT for Japanese cedar pollinosis. Methods Nasal swabs were taken in the preseason (n = 32) and in pollinosis season (n = 49) from subjects given sublingual drop immunotherapy for an average duration of 1.5 years. The numbers of metachromatic cells (mast cells and basophils), eosinophils and neutrophils were determined and compared with those from untreated subjects in preseason (n = 65) and in season (n = 54). Results SLIT subjects had a significantly reduced frequency of moderate to most severe symptoms in comparison to untreated subjects in preseason (P<br />The mechanisms underlying the effectiveness of sublingual immunotherapy (SLIT) for Japanese cedar pollinosis are poorly understood. One of mechanisms is a reduction of the number of metachromatic cells and eosinophils.
- Subjects :
- lcsh:Immunologic diseases. Allergy
Adult
Male
0301 basic medicine
medicine.medical_specialty
Adolescent
Cryptomeria
Immunology
Gastroenterology
Young Adult
03 medical and health sciences
0302 clinical medicine
subcutaneous immunotherapy
Internal medicine
Humans
Immunology and Allergy
Medicine
Eosinophilia
eosinophil
Sublingual immunotherapy
Aged
Original Research
Japanese cedar pollinosis
Sublingual Immunotherapy
business.industry
Metachromasia
Rhinitis, Allergic, Seasonal
Cedar pollinosis
Allergens
Middle Aged
Eosinophil
Slit
eye diseases
030104 developmental biology
medicine.anatomical_structure
Nasal Swab
Pollen
Female
sense organs
medicine.symptom
lcsh:RC581-607
mast cell
business
030215 immunology
Nasal symptoms
Subjects
Details
- ISSN :
- 20504527
- Volume :
- 8
- Database :
- OpenAIRE
- Journal :
- Immunity, Inflammation and Disease
- Accession number :
- edsair.doi.dedup.....df531913c7e60a6442043e48f573ea8a