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Ocular adnexal lymphoma and Helicobacter pylori gastric infection

Authors :
Claire Mathiot
J. Girodet
Nicole Brousse
Jean-Luc Beretti
Frédéric Mal
Corine Plancher
Bernard Asselain
Pierre Validire
Agnès Ferroni
Livia Lumbroso-Le Rouic
Kheira Beldjord
Patricia Validire
Patricia de Cremoux
Rémi Dendale
Anne Vincent-Salomon
E Macintyre
Marc Lecuit
Didier Decaudin
Olivier Hermine
Institut Curie [Paris]
CHU Necker - Enfants Malades [AP-HP]
Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)
Université Paris Descartes - Paris 5 (UPD5)
Institut Mutualiste de Montsouris (IMM)
Microorganismes et Barrières de l'Hôte (Equipe avenir)
Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Pasteur [Paris]
Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM)
Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM)
Institut Curie
Equipe avenir Microorganismes et Barrières de l'Hôte
Source :
American Journal of Hematology, American Journal of Hematology, Wiley, 2010, 85 (9), pp.645-649. ⟨10.1002/ajh.21765⟩, American Journal of Hematology, Wiley, 2010, 85 (9), pp.645. ⟨10.1002/ajh.21765⟩, American Journal of Hematology, 2010, 85 (9), pp.645-649. ⟨10.1002/ajh.21765⟩
Publication Year :
2010
Publisher :
Wiley, 2010.

Abstract

There is a causal association between Helicobacter pylori (Hp) gastric infection and the development of gastric MALT lymphoma. In contrast, the link between Hp gastric infection and the development of extragastric lymphoma has not been thoroughly investigated. We, therefore, studied the prevalence of gastric Hp infection at initial diagnosis of ophthalmologic and nonophthalmologic extragastric lymphoma patients. Three cohorts of patients were studied: a first one of 83 patients with OAL, a second one of 101 patients with extraophthalmologic extragastric lymphoma, and a third one of 156 control individuals (control) without malignant lymphoma. Gastric Hp infection was investigated by histopathological analysis and Hp-specific PCR assay on gastric biopsy tissue samples. We found gastric Hp infection in 37 OAL patients (45%), in 25 extraophthalmologic extragastric lymphoma cases (25%), and in 18 controls individuals (12%) (P < 0.0001 OAL/C and P < 0.01 OAL/extra-OAL cases). Gastritis was found in 51% and 9% of Hp-positive and Hp-negative lymphoma patients, respectively (P < 10−4). Gastric Hp infection only correlated with MALT/LPL lymphoma (P = 0.03). There is a significant association between gastric Hp infection and MALT/LPL OAL. This suggests a novel mechanism of indirect infection-associated lymphomagenesis whereby chronic local antigen stimulation would lead to the emergence of ectopic B-cell lymphoma. © 2010 Wiley-Liss, Inc. Am. J. Hematol.

Details

ISSN :
03618609 and 10968652
Volume :
85
Database :
OpenAIRE
Journal :
American Journal of Hematology
Accession number :
edsair.doi.dedup.....df63f01ba640726bcf502258e8672386