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Ocular adnexal lymphoma and Helicobacter pylori gastric infection
- Source :
- American Journal of Hematology, American Journal of Hematology, Wiley, 2010, 85 (9), pp.645-649. ⟨10.1002/ajh.21765⟩, American Journal of Hematology, Wiley, 2010, 85 (9), pp.645. ⟨10.1002/ajh.21765⟩, American Journal of Hematology, 2010, 85 (9), pp.645-649. ⟨10.1002/ajh.21765⟩
- Publication Year :
- 2010
- Publisher :
- Wiley, 2010.
-
Abstract
- There is a causal association between Helicobacter pylori (Hp) gastric infection and the development of gastric MALT lymphoma. In contrast, the link between Hp gastric infection and the development of extragastric lymphoma has not been thoroughly investigated. We, therefore, studied the prevalence of gastric Hp infection at initial diagnosis of ophthalmologic and nonophthalmologic extragastric lymphoma patients. Three cohorts of patients were studied: a first one of 83 patients with OAL, a second one of 101 patients with extraophthalmologic extragastric lymphoma, and a third one of 156 control individuals (control) without malignant lymphoma. Gastric Hp infection was investigated by histopathological analysis and Hp-specific PCR assay on gastric biopsy tissue samples. We found gastric Hp infection in 37 OAL patients (45%), in 25 extraophthalmologic extragastric lymphoma cases (25%), and in 18 controls individuals (12%) (P < 0.0001 OAL/C and P < 0.01 OAL/extra-OAL cases). Gastritis was found in 51% and 9% of Hp-positive and Hp-negative lymphoma patients, respectively (P < 10−4). Gastric Hp infection only correlated with MALT/LPL lymphoma (P = 0.03). There is a significant association between gastric Hp infection and MALT/LPL OAL. This suggests a novel mechanism of indirect infection-associated lymphomagenesis whereby chronic local antigen stimulation would lead to the emergence of ectopic B-cell lymphoma. © 2010 Wiley-Liss, Inc. Am. J. Hematol.
- Subjects :
- Male
Pathology
MESH: Eye Neoplasms
Gastroenterology
Cohort Studies
0302 clinical medicine
immune system diseases
hemic and lymphatic diseases
MESH: Lymphoma, B-Cell, Marginal Zone
Stomach cancer
MESH: Cohort Studies
[SDV.MP.MYC]Life Sciences [q-bio]/Microbiology and Parasitology/Mycology
MESH: Aged
MESH: Middle Aged
Hematology
biology
Stomach
digestive, oral, and skin physiology
Middle Aged
3. Good health
medicine.anatomical_structure
Gastritis
030220 oncology & carcinogenesis
Medicine
Female
MESH: Gastritis
medicine.symptom
Adult
medicine.medical_specialty
Helicobacter Infections
03 medical and health sciences
Ocular Adnexal Lymphoma
Internal medicine
medicine
Humans
Aged
Gastric Infection
MESH: Humans
Helicobacter pylori
business.industry
Eye Neoplasms
MESH: Helicobacter Infections
MESH: Adult
Lymphoma, B-Cell, Marginal Zone
biology.organism_classification
medicine.disease
digestive system diseases
MESH: Male
Lymphoma
030221 ophthalmology & optometry
MESH: Helicobacter pylori
business
MESH: Female
Subjects
Details
- ISSN :
- 03618609 and 10968652
- Volume :
- 85
- Database :
- OpenAIRE
- Journal :
- American Journal of Hematology
- Accession number :
- edsair.doi.dedup.....df63f01ba640726bcf502258e8672386