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Allogeneic stem cell transplantation for peripheral T cell lymphomas: a retrospective study in 285 patients from the Société Francophone de Greffe de Moelle et de Thérapie Cellulaire (SFGM-TC)
- Source :
- Journal of Hematology & Oncology, Journal of Hematology and Oncology, Journal of Hematology and Oncology, BioMed Central, 2020, 13 (1), pp.56. ⟨10.1186/s13045-020-00892-4⟩, Journal of Hematology and Oncology, BioMed Central, 2020, 13 (1), ⟨10.1186/s13045-020-00892-4⟩, Journal of Hematology and Oncology, 2020, 13 (1), pp.56. ⟨10.1186/s13045-020-00892-4⟩, Journal of Hematology & Oncology, Vol. 13, No 1 (2020) P. 56, Journal of Hematology & Oncology, Vol 13, Iss 1, Pp 1-12 (2020)
- Publication Year :
- 2020
- Publisher :
- Springer Science and Business Media LLC, 2020.
-
Abstract
- BackgroundPeripheral T cell lymphomas form a heterogeneous group with a usually dismal prognostic. The place of allogeneic stem cell transplantation to treat PTCL is debated.MethodsWe retrospectively analyzed the overall survival (OS), event-free survival (EFS), relapse, and transplant-related mortality (TRM) and associated variables in 285 adults with non-primary cutaneous PTCL (PCTL-NOS (39%), angioimmunoblastic T cell lymphomas (29%), anaplastic T cell lymphomas (15%), and other subtypes (17%)), who received alloSCT in 34 centers between 2006 and 2014.ResultsAlloSCT was given as part of front-line therapy (n= 138) to 93 patients in first complete response (CR) and 45 in first partial response (PR), and of salvage therapy (n= 147) to 116 patients for second or more CR/PR and 31 for progressive disease. Reduced-intensity conditioning (RIC) was given to 172 patients (62%), while 107 (38%) received myeloablative conditioning (MAC). The median follow-up was 72.4 months. The 2- and 4-year OS were 65% and 59%, respectively, and the cumulative incidence of relapse was 18% after 1 year and 19% after 2 years. TRM was 21% at 1 year, 24% after 2 years, and 28% after 4 years. In multivariate analysis, grade III–IV acute GvHD (HR = 2.57, 95% CI 1.53–4.31;p= 0.00036), low Karnofsky score < 80% (HR = 5.14, 95% CI 2.02–13.06;p= 0.00058), and progressive disease status before transplant (HR = 2.21, 95% CI 1.25–3.89;p =0.0062) were significantly associated with a reduced OS.ConclusionsThe data demonstrate in the largest retrospective cohort of non-cutaneous PTCL so far reported that alloSCT after RIC or MAC is an effective strategy, even in chemoresistant patients.
- Subjects :
- Cancer Research
Transplantation Conditioning
endocrine system diseases
Graft vs Host Disease
Salvage therapy
Kaplan-Meier Estimate
Gastroenterology
0302 clinical medicine
Recurrence
Antineoplastic Combined Chemotherapy Protocols
Cumulative incidence
ComputingMilieux_MISCELLANEOUS
ddc:616
Hematology
Incidence
Remission Induction
Hematopoietic Stem Cell Transplantation
[SDV.MHEP.HEM]Life Sciences [q-bio]/Human health and pathology/Hematology
lcsh:Diseases of the blood and blood-forming organs
Middle Aged
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Allografts
Prognosis
Combined Modality Therapy
Progression-Free Survival
3. Good health
Treatment Outcome
medicine.anatomical_structure
Oncology
030220 oncology & carcinogenesis
[SDV.IMM]Life Sciences [q-bio]/Immunology
Peripheral T cell lymphoma
Lymphoma, Large-Cell, Anaplastic
Immunosuppressive Agents
Adult
medicine.medical_specialty
Adolescent
Retrospective analysis
T cell
[SDV.CAN]Life Sciences [q-bio]/Cancer
Infections
lcsh:RC254-282
Young Adult
03 medical and health sciences
Internal medicine
medicine
Humans
neoplasms
Molecular Biology
Aged
Retrospective Studies
Salvage Therapy
lcsh:RC633-647.5
business.industry
Research
Lymphoma, T-Cell, Peripheral
Retrospective cohort study
medicine.disease
Peripheral T-cell lymphoma
Allogeneic stem cell transplantation
Transplantation
[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
Radiotherapy, Adjuvant
business
Progressive disease
030215 immunology
Subjects
Details
- ISSN :
- 17568722
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- Journal of Hematology & Oncology
- Accession number :
- edsair.doi.dedup.....df6b5f4ac8f04c9e0f1c42277548db27