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Integrated Multimodal Imaging of Dynamic Bone-Tumor Alterations Associated with Metastatic Prostate Cancer
- Source :
- PLoS ONE [E], 10(4). Public Library of Science, PLoS ONE, PLoS ONE, Vol 10, Iss 4, p e0123877 (2015), PLoS ONE, 10(4):e123877. Public Library of Science
- Publication Year :
- 2015
-
Abstract
- Bone metastasis occurs for men with advanced prostate cancer which promotes osseous growth and destruction driven by alterations in osteoblast and osteoclast homeostasis. Patients can experience pain, spontaneous fractures and morbidity eroding overall quality of life. The complex and dynamic cellular interactions within the bone microenvironment limit current treatment options thus prostate to bone metastases remains incurable. This study uses voxel-based analysis of diffusion-weighted MRI and CT scans to simultaneously evaluate temporal changes in normal bone homeostasis along with prostate bone metatastsis to deliver an improved understanding of the spatiotemporal local microenvironment. Dynamic tumor-stromal interactions were assessed during treatment in mouse models along with a pilot prospective clinical trial with metastatic hormone sensitive and castration resistant prostate cancer patients with bone metastases. Longitudinal changes in tumor and bone imaging metrics during delivery of therapy were quantified. Studies revealed that voxel-based parametric response maps (PRM) of DW-MRI and CT scans could be used to quantify and spatially visualize dynamic changes during prostate tumor growth and in response to treatment thereby distinguishing patients with stable disease from those with progressive disease (p
- Subjects :
- Male
Oncology
BIOMARKER
Pathology
Osteolysis
Bone density
Bone disease
FUNCTIONAL DIFFUSION MAP
lcsh:Medicine
PROGRESSION
Docetaxel
SDG 3 – Goede gezondheid en welzijn
Multimodal Imaging
030218 nuclear medicine & medical imaging
Mice
Prostate cancer
0302 clinical medicine
Bone Density
Prostate
PARAMETRIC RESPONSE MAP
lcsh:Science
Non-U.S. Gov't
Multidisciplinary
Diphosphonates
Research Support, Non-U.S. Gov't
Bone metastasis
Clinical Trial
Tumor Burden
3. Good health
THERAPY RESPONSE
Treatment Outcome
medicine.anatomical_structure
030220 oncology & carcinogenesis
ANDROGEN INDEPENDENCE
Taxoids
Research Article
medicine.medical_specialty
GLIOBLASTOMA
Antineoplastic Agents
Bone Neoplasms
Research Support
N.I.H
03 medical and health sciences
Breast cancer
SDG 3 - Good Health and Well-being
Research Support, N.I.H., Extramural
DW-MRI
Osteoclast
Internal medicine
medicine
Journal Article
Animals
Humans
BREAST-CANCER
Osteoblasts
business.industry
lcsh:R
Prostatic Neoplasms
Extramural
WEIGHTED MRI
medicine.disease
Disease Models, Animal
Diffusion Magnetic Resonance Imaging
lcsh:Q
business
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 10
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- PLoS ONE [E]
- Accession number :
- edsair.doi.dedup.....df7722cff6e5b7f04719f01143bd1124