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From Alkynes to Heterocycles through Metal-Promoted Silylformylation and Silylcarbocyclization Reactions
- Source :
- Catalysts, Vol 10, Iss 1012, p 1012 (2020)
- Publication Year :
- 2020
-
Abstract
- Oxygen and nitrogen heterocyclic systems are present in a large number of natural and synthetic compounds. In particular, oxa- and aza-silacyclane, tetrahydrofuran, benzofuran, cycloheptadifuranone, cycloheptadipyrrolone, pyrrolidine, lactone, lactam, phthalan, isochromanone, tetrahydroisoquinolinone, benzoindolizidinone, indoline and indolizidine scaffolds are present in many classes of biologically active molecules. Most of these contain a C=O moiety which can be easily introduced using carbonylative reaction conditions. In this field, intramolecular silylformylation and silylcarbocyclization reactions may afford heterocyclic compounds containing a carbonyl functional group together with a vinylsilane moiety which can be further transformed. Considering these two aspects, in this review a detailed analysis of the literature data regarding the application of silylformylation and silylcarbocyclization reactions to the synthesis of several heterocyclic derivatives is reported.
- Subjects :
- lcsh:Chemical technology
010402 general chemistry
alkynes
N-heterocycles
01 natural sciences
Catalysis
Pyrrolidine
lcsh:Chemistry
chemistry.chemical_compound
Moiety
lcsh:TP1-1185
O-heterocycles
Physical and Theoretical Chemistry
Benzofuran
Vinylsilane
silylformylation
silylcarbocyclization
010405 organic chemistry
Indolizidine
Combinatorial chemistry
0104 chemical sciences
lcsh:QD1-999
chemistry
Functional group
Indoline
Lactam
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Catalysts, Vol 10, Iss 1012, p 1012 (2020)
- Accession number :
- edsair.doi.dedup.....df82d00af97511b496c86e02c3fa7c7a