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Eunicellin-Based Diterpenoids, Hirsutalins N–R, from the Formosan Soft Coral Cladiella hirsuta
- Source :
- Marine Drugs; Volume 12; Issue 5; Pages: 2446-2457, Marine Drugs, Marine Drugs, Vol 12, Iss 5, Pp 2446-2457 (2014)
- Publication Year :
- 2014
- Publisher :
- Multidisciplinary Digital Publishing Institute, 2014.
-
Abstract
- New eunicellin-type hirsutalins N–R (1–5), along with two known eunicellins, (6 and 7) were isolated from the soft coral Cladiella hirsuta. The structures of the metabolites were determined by extensive spectroscopic analysis. Cytotoxic activity of compounds 1–7 against the proliferation of a limited panel of cancer cell lines was measured. The in vitro anti-inflammatory activity of compounds 1–7 was evaluated by measuring their ability in suppressing superoxide anion generation and elastase release in fMLP/CB-induced human neutrophils.
- Subjects :
- Models, Molecular
food.ingredient
Stereochemistry
Coral
Molecular Conformation
Taiwan
Pharmaceutical Science
Antineoplastic Agents
Article
chemistry.chemical_compound
food
Anthozoa
Cell Line, Tumor
Drug Discovery
Cladiella
Animals
Humans
anti-inflammatory activity
lcsh:QH301-705.5
Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
Eunicellin
biology
Superoxide
Elastase
Anti-Inflammatory Agents, Non-Steroidal
biology.organism_classification
In vitro
lcsh:Biology (General)
chemistry
Neutrophil Infiltration
Cladiella hirsuta
soft coral
eunicellins: cytotoxic activity
Cancer cell lines
Diterpenes
Subjects
Details
- Language :
- English
- ISSN :
- 16603397
- Database :
- OpenAIRE
- Journal :
- Marine Drugs; Volume 12; Issue 5; Pages: 2446-2457
- Accession number :
- edsair.doi.dedup.....dfa4c3b3180ec80402c41c3e60a8d9ac
- Full Text :
- https://doi.org/10.3390/md12052446