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Potential of anti-Candida antibodies in immunoprophylaxis
- Source :
- Immunotherapy. 2:171-183
- Publication Year :
- 2010
- Publisher :
- Future Medicine Ltd, 2010.
-
Abstract
- The need for new options for the treatment of invasive candidiasis has fuelled the use of antibodies in combination with conventional antifungal therapy. After a long period of time in which antibodies were considered irrelevant in the resistance against invasive candidiasis, it was demonstrated that a number of antibodies or their engineered derivatives directed against Candida albicans cell-wall polysaccharides and glycopeptides, as well as against some protein epitopes, confer protection against invasive candidiasis. This has confirmed this approach as a new strategy for the prophylaxis of invasive candidiasis. Of particular interest is Mycograb®, a human recombinant monoclonal antibody that inhibits heat shock protein 90, and has been administrated in combination with lipid-associated amphotericin B to patients with invasive candidiasis, and the fungicidal anti-β-glucan antibodies induced by the glycoconjugate vaccine composed of a β-glucan polysaccharide conjugated with the diphtheria toxoid CRM 197. However, despite the promising data obtained in vitro and in animal models, at present there is very little clinical experience on the use of antibodies in Candida immunoprophylaxis.
- Subjects :
- Adult
Antifungal Agents
Antigens, Fungal
medicine.drug_class
Immunology
Drug Evaluation, Preclinical
Antibodies, Monoclonal, Humanized
Monoclonal antibody
Epitope
Microbiology
Echinocandins
Lipopeptides
Mice
chemistry.chemical_compound
Bacterial Proteins
Double-Blind Method
Antigen
Caspofungin
Amphotericin B
Candida albicans
medicine
Animals
Humans
Immunology and Allergy
Child
Antibodies, Fungal
Randomized Controlled Trials as Topic
biology
Candidiasis
Immunization, Passive
Antibodies, Monoclonal
biology.organism_classification
Combined Modality Therapy
Mycoses
Oncology
Immunization
chemistry
Monoclonal
biology.protein
Fungal Vaccines
Antibody
Subjects
Details
- ISSN :
- 17507448 and 1750743X
- Volume :
- 2
- Database :
- OpenAIRE
- Journal :
- Immunotherapy
- Accession number :
- edsair.doi.dedup.....dfb158a2c6c4505a445454d6d085db2b