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Donkey-derived anti-CDV IgG, as a passive immunotherapy agent, can effectively increase survival rates of the experimental CDV-infected dogs
- Source :
- BMC Veterinary Research, Vol 17, Iss 1, Pp 1-12 (2021), BMC Veterinary Research
- Publication Year :
- 2021
- Publisher :
- Springer Science and Business Media LLC, 2021.
-
Abstract
- Background Humoral immunity plays an important role in the prevention of canine distemper. Anti-CD virus (CDV) antibody has strong antiviral activity and is widely used in the treatment of CD. However, with the increase of CD cases, the availability of therapeutic CD antibody fell short of the clinical needs. Results The high-titer antiserum with the high-titer neutralizing activity against CDV was obtained from the donkeys (Dezhou Donkey) immunized with the inactivated CDV vaccine. The donkey anti-CDV IgG was purified from the donkey serum, which was identified to significantly inhibit the CDV replication in the cultured Vero cells and effectively reduce the clinical symptoms and increase the survival rates (75%) of CDV-infected dogs (Shih-tzu Dog), similar to that treated with the dog-derived anti-CDV IgG. These results indicate that donkey-derived IgG is a potential substitute for dog-derived IgG to treat the CD in clinic. Conclusions Administration of donkey-derived anti-CDV IgG can ameliorate clinical symptoms and inhibit virus replication, thereby increasing the survival of CDV-infected dogs. This study opens up a new source of therapeutic antibody for CD treatment.
- Subjects :
- Canine distemper virus
Veterinary medicine
viruses
animal diseases
Therapeutic effects
Antibodies, Viral
Virus Replication
Virus
Passive immunotherapy
Dogs
Donkey
SF600-1100
medicine
Animals
Distemper
Distemper Virus, Canine
Antiserum
General Veterinary
biology
Canine distemper
business.industry
Immune Sera
Immunization, Passive
virus diseases
Equidae
General Medicine
medicine.disease
Virology
Survival Rate
Viral replication
Immunoglobulin G
Humoral immunity
biology.protein
Vero cell
Heterologous antibody
Antibody
business
Research Article
Subjects
Details
- ISSN :
- 17466148
- Volume :
- 17
- Database :
- OpenAIRE
- Journal :
- BMC Veterinary Research
- Accession number :
- edsair.doi.dedup.....dfbad38c2ae16218363d0e3daf7c4639