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Regulation of cellular senescence by extracellular matrix during chronic fibrotic diseases
- Source :
- Clinical Science (London, England : 1979), Clinical Science, 134(20), 2681-2706. PORTLAND PRESS LTD
- Publication Year :
- 2020
-
Abstract
- The extracellular matrix (ECM) is a complex network of macromolecules surrounding cells providing structural support and stability to tissues. The understanding of the ECM and the diverse roles it plays in development, homoeostasis and injury have greatly advanced in the last three decades. The ECM is crucial for maintaining tissue homoeostasis but also many pathological conditions arise from aberrant matrix remodelling during ageing. Ageing is characterised as functional decline of tissue over time ultimately leading to tissue dysfunction, and is a risk factor in many diseases including cardiovascular disease, diabetes, cancer, dementia, glaucoma, chronic obstructive pulmonary disease (COPD) and fibrosis. ECM changes are recognised as a major driver of aberrant cell responses. Mesenchymal cells in aged tissue show signs of growth arrest and resistance to apoptosis, which are indicative of cellular senescence. It was recently postulated that cellular senescence contributes to the pathogenesis of chronic fibrotic diseases in the heart, kidney, liver and lung. Senescent cells negatively impact tissue regeneration while creating a pro-inflammatory environment as part of the senescence-associated secretory phenotype (SASP) favouring disease progression. In this review, we explore and summarise the current knowledge around how aberrant ECM potentially influences the senescent phenotype in chronic fibrotic diseases. Lastly, we will explore the possibility for interventions in the ECM–senescence regulatory pathways for therapeutic potential in chronic fibrotic diseases.
- Subjects :
- 0301 basic medicine
Senescence
Aging
Cell Homeostasis & Autophagy
Antifibrotics
extracellular matrix
Disease
Cell Communication
Matrix (biology)
Molecular Bases of Health & Disease
Pathogenesis
Extracellular matrix
03 medical and health sciences
0302 clinical medicine
Fibrosis
medicine
Animals
Homeostasis
Humans
Review Articles
Cellular Senescence
DAMPs
business.industry
Senolytics
Mesenchymal stem cell
fibrosis
General Medicine
medicine.disease
030104 developmental biology
030220 oncology & carcinogenesis
Chronic Disease
Cell Cycle, Growth & Proliferation
Cancer research
Cell Migration, Adhesion & Morphology
business
Subjects
Details
- ISSN :
- 14708736 and 01435221
- Volume :
- 134
- Issue :
- 20
- Database :
- OpenAIRE
- Journal :
- Clinical science (London, England : 1979)
- Accession number :
- edsair.doi.dedup.....dfc660e431d7e46696ab68b3b25fd594