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Coordinated pyruvate kinase activity is crucial for metabolic adaptation and cell survival during mitochondrial dysfunction
- Source :
- Human Molecular Genetics
- Publication Year :
- 2021
- Publisher :
- Oxford University Press, 2021.
-
Abstract
- Deoxyguanosine kinase (DGUOK) deficiency causes mtDNA depletion and mitochondrial dysfunction. We reported long survival of DGUOK knockout (Dguok−/−) mice despite low (
- Subjects :
- 0301 basic medicine
AcademicSubjects/SCI01140
Mitochondrial DNA
Cell Survival
Citric Acid Cycle
Pyruvate Kinase
Adaptation, Biological
Deoxyguanosine kinase
Biology
DGUOK
DNA, Mitochondrial
Oxidative Phosphorylation
Serine
03 medical and health sciences
Mice
0302 clinical medicine
Genetics
Animals
Amino Acids
Molecular Biology
Genetics (clinical)
Mice, Knockout
Kinase
Membrane Proteins
General Medicine
Lipid Metabolism
Mitochondria
Citric acid cycle
030104 developmental biology
Biochemistry
Liver
Urea cycle
Cyclooxygenase 1
General Article
Energy Metabolism
030217 neurology & neurosurgery
Pyruvate kinase
Metabolic Networks and Pathways
Subjects
Details
- Language :
- English
- ISSN :
- 14602083 and 09646906
- Volume :
- 30
- Issue :
- 21
- Database :
- OpenAIRE
- Journal :
- Human Molecular Genetics
- Accession number :
- edsair.doi.dedup.....dfc81437d166c2abbf0d16df0e164b55