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Two Anti-anxiety Drugs: A Psychoneuroendocrine Study
- Source :
- BMJ. 2:202-205
- Publication Year :
- 1973
- Publisher :
- BMJ, 1973.
-
Abstract
- Eight males were studied during 27 weeks, including two periods of five weeks during which they received clinical doses of sodium amylobarbitone and benzoctamine. Substitution of placebo for either drug caused raised anxiety and impairment of mental concentration. The drugs reduced restlessness during sleep and reduced paradoxical sleep. By the fifth week of sodium amylobarbitone, although sleep was still less restless in the early night it was more restless than normal in the late night. Blood samples were taken half-hourly during sleep by indwelling venous catheter. Plasma growth hormone concentration was little affected during drug administration but rose temporarily after withdrawal. There was a reduction of plasma corticosteroid concentration during sleep throughout administration of the drugs and a rebound above normal during the first withdrawal week.
- Subjects :
- Adult
Male
Sleep Wake Disorders
Drug
Time Factors
medicine.drug_class
Amobarbital
media_common.quotation_subject
Sleep, REM
Placebo
Catheterization
Placebos
Adrenal Cortex Hormones
mental disorders
medicine
Humans
General Environmental Science
media_common
Anthracenes
Blood Specimen Collection
Clinical Trials as Topic
Sleep Stages
business.industry
General Engineering
Papers and Originals
General Medicine
Anxiety Disorders
Sleep in non-human animals
nervous system diseases
Substance Withdrawal Syndrome
body regions
Growth Hormone
Anesthesia
Benzoctamine
General Earth and Planetary Sciences
Corticosteroid
Anxiety
medicine.symptom
Sleep
business
medicine.drug
Subjects
Details
- ISSN :
- 14685833 and 09598138
- Volume :
- 2
- Database :
- OpenAIRE
- Journal :
- BMJ
- Accession number :
- edsair.doi.dedup.....dfdede5b40c80719e0c24b14efce73b9