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Goblet cells of the conjunctiva: A review of recent findings
Goblet cells of the conjunctiva: A review of recent findings
- Source :
- Progress in Retinal and Eye Research. 54:49-63
- Publication Year :
- 2016
- Publisher :
- Elsevier BV, 2016.
-
Abstract
- Goblet cells within the conjunctival epithelium are specialized cells that secrete mucins onto the surface of the eye. Recent research has demonstrated new characteristics of the cells, including factors influencing their differentiation, their gene products and their functions at the ocular surface. The following review summarizes the newly discovered aspects of the role of Spdef, a member of the Ets transcription factor family in conjunctival goblet cell differentiation, the newly discovered goblet cell products including claudin2, the Wnt inhibitor Frzb, and the transmembrane mucin Muc16. The current concepts of conjunctival goblet cell function, including debris removal and immune surveillance are reviewed, as are changes in the goblet cell population in ocular surface diseases. Major remaining questions regarding conjunctival cell biology are discussed.
- Subjects :
- 0301 basic medicine
Pathology
medicine.medical_specialty
Conjunctiva
Cellular differentiation
Population
Biology
Article
03 medical and health sciences
0302 clinical medicine
medicine
Animals
Humans
Claudin
education
Glycoproteins
Goblet cell
education.field_of_study
Proto-Oncogene Proteins c-ets
ETS transcription factor family
Mucin
Intracellular Signaling Peptides and Proteins
Mucins
Membrane Proteins
Cell Differentiation
respiratory system
Sensory Systems
Cell biology
Ophthalmology
030104 developmental biology
medicine.anatomical_structure
Frzb
CA-125 Antigen
Claudins
030221 ophthalmology & optometry
Goblet Cells
Subjects
Details
- ISSN :
- 13509462
- Volume :
- 54
- Database :
- OpenAIRE
- Journal :
- Progress in Retinal and Eye Research
- Accession number :
- edsair.doi.dedup.....dfe086dd9bdb33fa6bddcbc445fa65ee
- Full Text :
- https://doi.org/10.1016/j.preteyeres.2016.04.005