Back to Search
Start Over
Specific antibody responses against membrane proteins of erythrocytes infected by Plasmodium falciparum of individuals briefly exposed to malaria
- Source :
- Malaria Journal, Vol 9, Iss 1, p 276 (2010), Malaria Journal, Malaria Journal, BioMed Central, 2010, 9 (1), pp.276. ⟨10.1186/1475-2875-9-276⟩, Malaria Journal, 2010, 9 (1), pp.276. ⟨10.1186/1475-2875-9-276⟩
- Publisher :
- Springer Nature
-
Abstract
- Background Plasmodium falciparum infections could lead to severe malaria, principally in non-immune individuals as children and travellers from countries exempted of malaria. Severe malaria is often associated with the sequestration of P. falciparum-infected erythrocytes in deep micro-vascular beds via interactions between host endothelial receptors and parasite ligands expressed on the surface of the infected erythrocyte. Although, serological responses from individuals living in endemic areas against proteins expressed at surface of the infected erythrocyte have been largely studied, seldom data are available about the specific targets of antibody response from travellers. Methods In order to characterize antigens recognized by traveller sera, a comparison of IgG immune response against membrane protein extracts from uninfected and P. falciparum-infected red blood cells (iRBC), using immunoblots, was performed between non exposed individuals (n = 31) and briefly exposed individuals (BEI) (n = 38) to malaria transmission. Results Immune profile analysis indicated that eight protein bands from iRBC were significantly detected more frequently in the BEI group. Some of these antigenic proteins were identified by an original immuno-proteomic approach. Conclusion Collectively, these data may be useful to characterize the singular serological immune response against a primary malaria infection in individuals briefly exposed to transmission.
- Subjects :
- Male
Erythrocytes
lcsh:Arctic medicine. Tropical medicine
lcsh:RC955-962
030231 tropical medicine
Immunoblotting
Plasmodium falciparum
Immunoglobulin G
Serology
lcsh:Infectious and parasitic diseases
03 medical and health sciences
0302 clinical medicine
Immune system
[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases
parasitic diseases
medicine
Humans
lcsh:RC109-216
Malaria, Falciparum
MESH: Plasmodium falciparum
030304 developmental biology
MESH: Immunoglobulin G
0303 health sciences
MESH: Humans
biology
MESH: Immunoblotting
MESH: Erythrocytes
MESH: Malaria, Falciparum
Research
Membrane Proteins
medicine.disease
biology.organism_classification
Virology
MESH: Antibody Formation
MESH: Male
3. Good health
Infectious Diseases
Parasitology
Membrane protein
Immunology
Antibody Formation
[SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases
biology.protein
MESH: Membrane Proteins
Antibody
Malaria
Subjects
Details
- Language :
- English
- ISSN :
- 14752875
- Volume :
- 9
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Malaria Journal
- Accession number :
- edsair.doi.dedup.....dfeeca40b8d92886a6d39a46cb88264c
- Full Text :
- https://doi.org/10.1186/1475-2875-9-276