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Pre- and Postnatal Dietary Exposure to a Pesticide Cocktail Disrupts Ovarian Functions in 8-Week-Old Female Mice
- Source :
- International Journal of Molecular Sciences; Volume 23; Issue 14; Pages: 7525, International Journal of Molecular Sciences, International Journal of Molecular Sciences, MDPI, 2022, 23 (14), pp.7525. ⟨10.3390/ijms23147525⟩, International Journal of Molecular Sciences, 2022, 23 (14), pp.7525. ⟨10.3390/ijms23147525⟩
- Publication Year :
- 2022
- Publisher :
- Multidisciplinary Digital Publishing Institute, 2022.
-
Abstract
- International audience; Female infertility has a multifactorial origin, and exposure to contaminants, including pesticides, with endocrine-disrupting properties is considered to be involved in this reproductive disorder, especially when it occurs during early life. Pesticides are present in various facets of the environment, and consumers are exposed to a combination of multiple pesticide residues through food intake. The consequences of such exposure with respect to female fertility are not well known. Therefore, we aimed to assess the impact of pre- and postnatal dietary exposure to a pesticide mixture on folliculogenesis, a crucial process in female reproduction. Mice were exposed to the acceptable daily intake levels of six pesticides in a mixture (boscalid, captan, chlorpyrifos, thiacloprid, thiophanate and ziram) from foetal development until 8 weeks old. Female offspring presented with decreased body weight at weaning, which was maintained at 8 weeks old. This was accompanied by an abnormal ovarian ultrastructure, a drastic decrease in the number of corpora lutea and progesterone levels and an increase in ovary cell proliferation. In conclusion, this study shows that this pesticide mixture that can be commonly found in fruits in Europe, causing endocrine disruption in female mice with pre- and postnatal exposure by disturbing folliculogenesis, mainly in the luteinisation process.
- Subjects :
- pesticide
folliculogenesis
ovary
endocrine disruption
progesterone
[SDV]Life Sciences [q-bio]
Organic Chemistry
Pesticide Residues
General Medicine
Catalysis
Computer Science Applications
[SDV] Life Sciences [q-bio]
Inorganic Chemistry
Dietary Exposure
Mice
Fruit
Animals
Female
Chlorpyrifos
Physical and Theoretical Chemistry
Pesticides
Molecular Biology
Spectroscopy
Subjects
Details
- Language :
- English
- ISSN :
- 14220067 and 16616596
- Database :
- OpenAIRE
- Journal :
- International Journal of Molecular Sciences; Volume 23; Issue 14; Pages: 7525
- Accession number :
- edsair.doi.dedup.....e00bb91bb4288030117f563cc39f966e
- Full Text :
- https://doi.org/10.3390/ijms23147525