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Podoplanin Expression in Cancer-associated Fibroblasts Predicts Poor Prognosis in Patients with Squamous Cell Carcinoma of the Lung
- Source :
- Anticancer Research. 37:207-214
- Publication Year :
- 2017
- Publisher :
- Anticancer Research USA Inc., 2017.
-
Abstract
- Background/Aim: Podoplanin is a candidate cancer stem cell marker in squamous cell carcinoma (SCC). Several studies have reported the prognostic value of podoplanin expression in tumor cells in lung SCC but few have focused on its expression in cancer-associated fibroblasts (CAFs). The aim of this study was to analyze the prognostic significance of podoplanin expression, with special reference to the expression pattern in both tumor cells and CAFs. Patients and Methods: Immunohistochemical analyses using anti-podoplanin antibody were performed on 126 resected specimens of lung SCC. When more than 10% of tumor cells or CAFs showed immunoreactivity with podoplanin levels as strong as those of the positive controls, the specimens were classified as a podoplanin-positive. Results: Podoplanin-positive status in tumor cells (n=54) was correlated with a lower incidence of lymphatic invasion (p=0.031) but there were no significant differences in disease-free survival (DFS) and disease-specific survival (DSS) by the log-rank test. Podoplanin-positive status in CAFs (n=41) was correlated with more advanced stage (p=0.008), higher frequency of pleural invasion (p=0.002) and both shorter DFS (p=0.006) and DSS (p=0.006). In Cox's multivariate analysis, podoplanin-positive status in CAFs was an independent negative prognostic factor for DFS (p=0.027) and DSS (p=0.027). Conclusion: Podoplanin expression in CAFs might be an independent unfavorable prognostic indicator in patients with lung SCC, irrespective of the expression status of tumor cells.
- Subjects :
- Male
0301 basic medicine
Oncology
Cancer Research
medicine.medical_specialty
Lung Neoplasms
Lymphovascular invasion
Kaplan-Meier Estimate
03 medical and health sciences
0302 clinical medicine
Cancer-Associated Fibroblasts
Cancer stem cell
Internal medicine
medicine
Humans
Aged
Aged, 80 and over
Membrane Glycoproteins
Squamous-cell carcinoma of the lung
Lung
biology
business.industry
General Medicine
Prognosis
stomatognathic diseases
030104 developmental biology
medicine.anatomical_structure
Podoplanin
030220 oncology & carcinogenesis
Carcinoma, Squamous Cell
biology.protein
Immunohistochemistry
Female
Antibody
business
Subjects
Details
- ISSN :
- 17917530 and 02507005
- Volume :
- 37
- Database :
- OpenAIRE
- Journal :
- Anticancer Research
- Accession number :
- edsair.doi.dedup.....e01ac85783d23f1b6a2792843e580497
- Full Text :
- https://doi.org/10.21873/anticanres.11308