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Inter- and intra-reader agreement for gadoxetic acid-enhanced MRI parameter readings in patients with chronic liver diseases
- Source :
- Beer, Lucian; Mandorfer, Mattias; Bastati, Nina; Poetter-Lang, Sarah; Tamandl, Dietmar; Stoyanova, Dilyana Plamenova; et al.(2019). Inter-and intra-reader agreement for gadoxetic acid-enhanced MRI parameter readings in patients with chronic liver diseases.. European radiology. doi: 10.1007/s00330-019-06182-z. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/5mj8h0w7, European Radiology, European radiology, vol 29, iss 12
- Publication Year :
- 2019
- Publisher :
- eScholarship, University of California, 2019.
-
Abstract
- Objectives To examine inter- and intra-observer agreement for four simple hepatobiliary phase (HBP)–based scores on gadoxetic acid (GA)–enhanced MRI and their correlation with liver function in patients with mixed chronic liver disease (CLD). Methods This single-center, retrospective study included 287 patients (62% male, 38% female, mean age 53.5 ± 13.7 years) with mixed CLD (20.9% hepatitis C, 19.2% alcoholic liver disease, 8% hepatitis B) who underwent GA-enhanced MRI of the liver for clinical care between 2010 and 2015. Relative liver enhancement (RLE), contrast uptake index (CUI), hepatic uptake index (HUI), and liver-to-spleen contrast index (LSI) were calculated by two radiologists independently using unenhanced and GA-enhanced HPB (obtained 20 min after GA administration) images; 50 patients selected at random were reviewed twice by one reader to assess intra-observer reliability. Agreement was assessed by intraclass correlation coefficient (ICC). The albumin-bilirubin (ALBI) score, the model of end-stage liver disease (MELD), and the Child-Turcotte-Pugh (CTP) score were calculated as standards of reference for hepatic function. Results Intra-observer ICCs ranged from 0.814 (0.668–0.896) for CUI to 0.969 (0.945–0.983) for RLE. Inter-observer ICCs ranged from 0.777 (0.605–0.874) for HUI to 0.979 (0.963–0.988) for RLE. All HBP-based scores correlated significantly (all p
- Subjects :
- Gadolinium DTPA
Male
Alcoholic liver disease
Intraclass correlation
Gadoxetic acid
Contrast Media
Chronic liver disease
Gastroenterology
030218 nuclear medicine & medical imaging
Liver disease
0302 clinical medicine
80 and over
Liver function tests
Magnetic Resonance
Aged, 80 and over
medicine.diagnostic_test
Liver Diseases
General Medicine
Hepatitis C
Middle Aged
Magnetic Resonance Imaging
Nuclear Medicine & Medical Imaging
Liver
030220 oncology & carcinogenesis
Female
Radiology
medicine.drug
Adult
medicine.medical_specialty
Adolescent
Clinical Sciences
and over
Young Adult
03 medical and health sciences
Magnetic resonance imaging
Internal medicine
medicine
Humans
Radiology, Nuclear Medicine and imaging
Liver diseases
Aged
Retrospective Studies
business.industry
Reproducibility of Results
medicine.disease
ROC Curve
Chronic Disease
Liver function
business
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Beer, Lucian; Mandorfer, Mattias; Bastati, Nina; Poetter-Lang, Sarah; Tamandl, Dietmar; Stoyanova, Dilyana Plamenova; et al.(2019). Inter-and intra-reader agreement for gadoxetic acid-enhanced MRI parameter readings in patients with chronic liver diseases.. European radiology. doi: 10.1007/s00330-019-06182-z. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/5mj8h0w7, European Radiology, European radiology, vol 29, iss 12
- Accession number :
- edsair.doi.dedup.....e02984247b49e293e4b5ab8cb62c2a1b
- Full Text :
- https://doi.org/10.1007/s00330-019-06182-z.