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The aberrant expression of rhythm genes affects the genome instability and regulates the cancer immunity in pan-cancer
- Source :
- Cancer Medicine, Cancer Medicine, Vol 9, Iss 5, Pp 1818-1829 (2020)
- Publication Year :
- 2019
-
Abstract
- Although emerging studies showed that certain rhythm genes regulate cancer progression, the expression and roles of the vast majority of rhythm genes in human cancer are largely unknown, and the hallmarks of cancer regulated by rhythm genes have not been detected. In this study, we detected the expression changes of rhythm genes in panācancer and found that almost all rhythm genes mutated in all cancer types, and their expression level was significantly altered partially due to abnormal methylation, and several rhythm genes regulate the expression of other rhythm genes in various cancer types. Furthermore, we revealed that rhythm genes are significantly enriched in genome instability and the expression of certain rhythm genes is correlated with the tumor mutation burden, microsatellite instability, and the expression of DNA damage repair genes in most of the detected cancer types. Moreover, rhythm genes are associated with the infiltration of immune cells and the efficiency of immune blockade therapy. This study provides a comprehensive understanding of the roles of rhythm genes in cancer immunity, which may provide a novel method for the diagnosis and treatment of cancer.<br />We reported that almost all rhythm genes mutated in all cancer types, and their expression level was significantly altered partially due to abnormal methylation and a series of functions of rhythm genes in tumor development. Rhythm genes are associated with the infiltration of immune cells and the efficiency of immune blockade therapy. This study provides a comprehensive understanding of the roles of rhythm genes in cancer immunity, which may provide a novel method for the diagnosis and treatment of cancer.
- Subjects :
- 0301 basic medicine
Genome instability
Cancer Research
DNA Repair
Datasets as Topic
Biology
lcsh:RC254-282
Genomic Instability
03 medical and health sciences
0302 clinical medicine
Immune system
Rhythm
cancer immunity
Neoplasms
medicine
Biomarkers, Tumor
Humans
Radiology, Nuclear Medicine and imaging
Neoplasm Invasiveness
Gene
Immune Checkpoint Inhibitors
Original Research
Cancer Biology
Circadian Rhythm Signaling Peptides and Proteins
Gene Expression Profiling
Microsatellite instability
Computational Biology
Methylation
DNA Methylation
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
medicine.disease
genome instability
Blockade
Gene Expression Regulation, Neoplastic
030104 developmental biology
The Hallmarks of Cancer
Oncology
Drug Resistance, Neoplasm
030220 oncology & carcinogenesis
Cancer research
circadian rhythm genes
microsatellite instability
DNA Damage
Subjects
Details
- ISSN :
- 20457634
- Volume :
- 9
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Cancer medicine
- Accession number :
- edsair.doi.dedup.....e03da29548db94872af07e14f74b2a38