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Histopathology of the lung following intratracheal challenge with livePseudomonas aeruginosain intestinally immunized rats
- Source :
- Immunology and Cell Biology. 73:440-445
- Publication Year :
- 1995
- Publisher :
- Wiley, 1995.
-
Abstract
- This paper examines the histology of rat lungs following intestinal immunization with killed mucoid Pseudomonas aeruginosa and subsequent pulmonary challenge with live P. aeruginosa. The lungs of non-immune challenged rats developed a confluent haemorrhagic pneumonitis with degeneration and sloughing of the mucosa of the airways; perivascular infiltration with mononuclear cells was apparent 1-2 h post-challenge; some neutrophils were present by 2 h post-challenge; by 12 h post-challenge oedema and intra-alveolar haemorrhage were prominent and Gram-negative organisms were seen in large quantities. In contrast, immunized challenged animals showed a pronounced neutrophilic response 1-2 h post challenge; by 12 h post-challenge patchy abscesses were apparent with resolving inflammation and no organisms visible. The findings suggest that intestinal immunization prevents the development of fatal P. aeruginosa infections in the lung by accelerating the recruitment of polymorphonuclear neutrophils.
- Subjects :
- Male
0301 basic medicine
medicine.medical_specialty
Pathology
Neutrophils
Immunology
Inflammation
medicine.disease_cause
Peripheral blood mononuclear cell
Microbiology
Peyer's Patches
03 medical and health sciences
0302 clinical medicine
Animals
Immunology and Allergy
Medicine
Pseudomonas Infections
Lung
Pneumonitis
business.industry
Pseudomonas aeruginosa
Vaccination
Histology
Cell Biology
medicine.disease
Rats
Specific Pathogen-Free Organisms
Chemotaxis, Leukocyte
030104 developmental biology
medicine.anatomical_structure
Vaccines, Inactivated
Histopathology
medicine.symptom
business
Infiltration (medical)
030215 immunology
Subjects
Details
- ISSN :
- 08189641
- Volume :
- 73
- Database :
- OpenAIRE
- Journal :
- Immunology and Cell Biology
- Accession number :
- edsair.doi.dedup.....e06f3ab4cf4ee4ea1292f240f54a71a7