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Clinical and Histopathological Features of Genitourinary Sarcomas: Our Experiences and Case Series at a Single Center

Authors :
İsmail Selvi
Eşref Oğuz Güven
Source :
Üroonkoloji Bülteni, Vol 18, Iss 3, Pp 93-98 (2019)
Publication Year :
2019
Publisher :
Galenos Yayinevi, 2019.

Abstract

Objective: The incidence of genitourinary sarcomas is very low, so the published reports in the literature are very limited. We aimed to present our experiences of eight cases originating from various genitourinary organs treated in our clinic. Materials and Methods: We retrospectively reviewed the data and postoperative follow-up findings of eight cases aged 3-72 years who were diagnosed as genitourinary sarcoma and treated between January 2013 and February 2017. Results: All eight cases were male and the mean age at diagnosis was 47.87 (range = 3-72) years. The most common site was paratesticular area (five cases, 62.5%) followed by kidney (two cases, 25%) and prostate (one case, 12.5%). Histological types of tumors were rhabdomyosarcoma (RMS) (two cases, 25%), liposarcoma (LPS) (two cases, 25%), leiomyosarcoma (LMS) (two cases, 25%), synovial sarcoma (one case, 12.5%) and malignant fibrous histiostoma (MFH) (one case, 12.5%). At a median follow-up of 23.5 (range = 4-62) months, the recurrence-free and progression-free survival rate was 50%, while the overall survival rate was 50%. Among the five paratesticular sarcomas, the worst prognosis was seen in LMS (local recurrence at the 4th, overall survival was 28 months) and MFH (local recurrence at the 8th, overall survival was 33 months). Among all sarcoma cases, LMS and synovial sarcoma were the histologic types with the worst prognosis. The histological types with the best prognosis were LPS and RMS with no recurrence or progression during follow-up. In all cases with a median tumor size of 52.5 mm (range = 11-210), LPS was found to have a better prognosis, although the largest tumor size was in renal LPS. According to FNCLCC classifications, local recurrence-free survival was significantly higher in grade II sarcomas than in grade III (p=0.042). Conclusion: Histopathological features and oncologic outcomes of genitourinary sarcomas differ. The prognosis of paratesticular sarcomas is better than other genitourinary organ sarcomas. LPS has higher cure rates after treatment in histological subtypes. The prognosis of histopathologically poorly differentiated subtypes and high-grade tumors is poor. If adjuvant treatments are not added, they may be fatal with local recurrence or distant metastasis in a short time.

Subjects

Subjects :
Cultural Studies
lcsh:Internal medicine
medicine.medical_specialty
62.5%) followed by kidney (two cases
paratesticular sarcomas
lcsh:Specialties of internal medicine
overall survival
lcsh:Medicine
Objective: The incidence of genitourinary sarcomas is very low
lcsh:RC870-923
Single Center
lcsh:RC254-282
12.5%). Histological types of tumors were rhabdomyosarcoma (RMS) (two cases
liposarcoma (LPS) (two cases
the recurrence-free and progression-free survival rate was 50%
overall survival was 28 months) and MFH (local recurrence at the 8th
although the largest tumor size was in renal LPS. According to FNCLCC classifications
lcsh:RC581-951
Medicine
25%)
leiomyosarcoma (LMS) (two cases
synovial sarcoma (one case
lcsh:RC31-1245
while the overall survival rate was 50%. Among the five paratesticular sarcomas
the worst prognosis was seen in LMS (local recurrence at the 4th
Series (stratigraphy)
so the published reports in the literature are very limited. We aimed to present our experiences of eight cases originating from various genitourinary organs treated in our clinic. Materials and Methods: We retrospectively reviewed the data and postoperative follow-up findings of eight cases aged 3-72 years who were diagnosed as genitourinary sarcoma and treated between January 2013 and February 2017. Results: All eight cases were male and the mean age at diagnosis was 47.87 (range = 3-72) years. The most common site was paratesticular area (five cases
25%) and prostate (one case
business.industry
Genitourinary system
lcsh:R
overall survival was 33 months). Among all sarcoma cases
LMS and synovial sarcoma were the histologic types with the worst prognosis. The histological types with the best prognosis were LPS and RMS with no recurrence or progression during follow-up. In all cases with a median tumor size of 52.5 mm (range = 11-210)
Religious studies
genitourinary sarcomas
lcsh:Diseases of the genitourinary system. Urology
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
12.5%). At a median follow-up of 23.5 (range = 4-62) months
LPS was found to have a better prognosis
Radiology
business
12.5%) and malignant fibrous histiostoma (MFH) (one case
FNCLCC grading system
local recurrence-free survival was significantly higher in grade II sarcomas than in grade III (p=0.042). Conclusion: Histopathological features and oncologic outcomes of genitourinary sarcomas differ. The prognosis of paratesticular sarcomas is better than other genitourinary organ sarcomas. LPS has higher cure rates after treatment in histological subtypes. The prognosis of histopathologically poorly differentiated subtypes and high-grade tumors is poor. If adjuvant treatments are not added

Details

ISSN :
21472270 and 21472122
Volume :
18
Database :
OpenAIRE
Journal :
The Bulletin of Urooncology
Accession number :
edsair.doi.dedup.....e08d74723aea6ea4fd7572e29ae43a56
Full Text :
https://doi.org/10.4274/uob.galenos.2019.1193